COSMOSIL HPLC Columns
COSMOSIL Column List
| Sample | Separation Mode | Packing Material | USP Code | Stationary Phase |
Special Features and Applications |
|---|---|---|---|---|---|
| Organic Compounds (low M.W.) |
Reversed Phase |
3C18-EB |
Octadecyl Group |
- Excellent for basic compounds - 3 µm silica packing material |
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| C18-MS-II | L1 | Octadecyl Group |
- Multi-purpose C18column - Monofunctional silylation on ultra-pure silica gel for separation of the widest range of compounds |
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| C18-AR-II | L1 | -Features strong acid resistance and suitable for acidic compounds and peptides | |||
| C18-PAQ | L1 | - Reversed phase column, compatible with 100% water based mobile phase. - Suitable for hydrophilic compounds |
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| Cholester | - | Cholesteryl Group |
- Usable under the same condition as C18 - Unique rigid cholesteryl structure improves separation |
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| πNAP | - | Naphtylethyl Group |
- Stronger π-π interaction than Phenyl column | ||
| PYE | - | Pyrenylethyl Group |
- Most powerful π-π interaction | ||
| NPE | - | Nitrophenylethyl Group |
- Separation utilizing π-π interaction and dipole-dipole interaction | ||
| PBB-R | - | Pentabromobenzyl Group |
- Separation utilizing dispersion force | ||
| C22-AR-II | - | Docosyl Group |
- Alkyl chain columns except C18column | ||
| C8-MS | L7 | Octyl Group |
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| C4-MS | L26 | Butyl Group |
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| TMS-MS | L13 | Trimethyl Group |
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| PE-MS | L11 | Phenylethyl Group |
- π-π interaction | ||
| CN-MS | L10 | Cyanopropyl Group |
- Great reproducibility using isocratic elution mode | ||
| Normal Phase |
SL-II | L3 | - | - Suitable for preparative separation | |
| Hydrophilic Interaction |
HILIC | - | Triazole | - Retains highly polar compounds that would not be retained in C18column | |
| Monosaccharides Oligosaccharides |
Hydrophilic Interaction |
Sugar-D | - | Secondary/Tertiary Amine | - Suitable for monosaccharides, oligosaccharides |
| NH2-MS | - | Aminopropyl Group |
- Primary amine bonded column | ||
| Proteins | Reversed Phase |
Protein-R | - | Octadecyl Group |
- Provides improved separation, high recovery rate, and acid resistance |
| C18-AR-300 | L1 | Octadecyl Group |
- Wide pore type reversed phase columns | ||
| C8-AR-300 | L7 | Octyl Group |
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| C4-AR-300 | L26 | Butyl Group |
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| Ph-AR-300 | L11 | Phenyl Group |
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| Proteins | Gel Permeation |
Diol-120-II | L20 | Diol Group | - Silica-based gel filtration column Selection of pore size: 5,000-100,000 |
| Diol-300-II | L20 | - Silica-based gel filtration column Selection of pore size: 10,000-700,000 |
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| Ion-exchange | Type Q | Quaternary Ammonium Type | - Anion-exchange Type - For Purification - Target Sample: Acidic Proteins / DNA |
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| Type Q-N | - Anion-exchange Type - For Ultra-fast Analysis, Precise Analysis - Target Sample: Acidic Proteins / DNA |
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| Type S | Sulfopropyl Type | - Cation-exchange Type - For Purification - Target Sample: Basic Proteins |
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| Type S-N | - Cation-exchange Type - For Ultra-fast Analysis, Precise Analysis - Target Sample: Basic Proteins |
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| Type M | Quaternary Ammonium Type/ Sulfopropyl Type |
- Amphoteric ion-exchange Type - For Purification - Target Sample: All Proteins |
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| Type M-N | - Amphoteric ion-exchange Type - For Precise Analysis - Target Sample: All Proteins |
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| Hydrophobic Interaction |
HIC | - | - | - Suitable for separation of peptide, and there is only a little less in enzyme activity and the teriary structure of proteins | |
| Fullerenes | - | Buckyprep | - | Pyrenylpropyl Group |
- Standard column for fullerene separation |
| Buckyprep-D |
- | Nitro-carbazoyl Group | - Designed for separation of fullerene derivatives | ||
| Buckyprep-M | - | Phenothiazinyl Group |
- Designed to separate metallofullerenes | ||
| PBB | - | Pentabromobenzyl Group |
- Designed for preparative separation of C60, C70 | ||
| PYE | - | Pyrenylethyl Group |
- Separation of Fullerenes and structural isomers | ||
| NPE | - | Nitrophenylethyl Group |
- Separation of derivatived fullerene | ||
| Carbon Nanotubes |
Gel Permeation |
CNT | Hydrophilic Group |
- separation of carbon nanotubes |
Selection Guide
Organic Compounds (Low M.W.)
Octadecyl group bonded column (C18ODS) are recommended as first-choice columns for separations of organic compounds (Low M.W.). If there is not enough separation or no retention using COSMOSIL C18 columns, COSMOSIL series offer many kinds of special columns.
Please click here for the selection guide for C18 columns
Saccharides
- COSMOSIL Sugar-D is recommended for the separation of monosaccharides and oligosaccharides as a first-choice column.
- For the separation of sugar derivatives, COSMOSIL C18-PAQ is suitable as well.
Proteins
- Please select based on the separation mode.
Fullerenes
- COSMOSIL Buckyprep is most suitable for the separation of fullerenes.
COSMOSIL Specilty Columns
COSMOSIL Specialty columns (PDF)USP Specifications
The USP (U.S. Pharmacopeia) specifications are listed below with the recommended COSMOSIL HPLC columns.
| USP Code | Description | Recommended Columns |
|---|---|---|
| L1 | Octadecyl silane chemically bonded to porous silica or ceramic micro-particles, 1.7 to 10 m in diameter, or a monolithic rod | COSMOSIL C18-MS-II COSMOSIL C18-AR-II COSMOSIL C18-PAQ COSMOSIL C18-AR-300 |
| L3 | Porous silica particles, 5 to 10 m in diameter | COSMOSIL SL-II |
| L7 | Octylsilane chemically bonded to totally porous silica particles, 1.7 to 10 m in diameter | COSMOSIL C8-MS COSMOSIL C8-AR-300 |
| L10 | Nitrile groups chemically bonded to porous silica particles, 3 to 10 m in diameter | COSMOSIL CN-MS |
| L11 | Phenyl groups chemically bonded to porous silica particles, 1.7 to 10 m in diameter | COSMOSIL PE-MS COSMOSIL Ph-AR-300 |
| L13 | Trimethylsilane chemically bonded to porous silica particles, 3 to 10 m in diamete | COSMOSIL TMS-MS |
| L20 | Dihydroxypropane groups chemically bonded to porous silica particles, 5 to 10 m in diameter | COSMOSIL Diol-120-II COSMOSIL Diol-300-II |
| L26 | Butyl silane chemically bonded to totally porous silica particles, 3 to 10 m in diameter | COSMOSIL C4-MS COSMOSIL C4-AR-300 |