LIQUID CHROMATOGRAPHY RELATED PRODUCTS

Open column chromatography is an excellent and easy technique for large-scale preparation and purification at low cost. COSMOSIL offers both normal and reversed phase packing materials based on totally porous spherical silica, which provides higher separation, less pressure and higher reproducibility than irregular silica.

for reversed phase
for normal phase

Packing materials for reversed phase preparative liquid chromatography

Material characteristics

Packing material C18-OPN C18-PREP
Silica gel high purity porous spherical silica
Average particle size 75･140 µm 40･75･140 µm
Average pore size approx. 120Å
Specific surface area approx. 300 m2/g
Stationary phase octadecyl group
Carbon content - approx. 19%
End capping treatment - treated

Useful range of C18-OPN and C18-PREP

Open column
chromatography		 concentration of
organic solvent		 75C18-OPN
140C18-OPN		 40C18-PREP 75C18-PREP
140C18-PREP
70% or less +++ - -
70% or more ++ + +++
Middle pressure column chromatography + +++ ++

+++ : very suitable, ++ : suitable, + : applicable, - : not applicable

Selection guide

How to select C18 preparative packing materials.

Selection guide PR

Selection guide

Figure. Packing material in water
Left: C18-OPN provides good resolution
Right: C18-PREP float up

Packing materials for normal phase preparative liquid chromatography

Material characteristics

Packing material SL-II-PREP Silica gel 60 neutral
Silica gel high purity porous spherical silica
Average particle size 75 µm 140 µm 75 µm 140 µm
Average pore size approx. 120Å approx. 60Å
Specific surface area approx. 300 m2/g approx. 500 m2/g
Application Open column chromatography/Flash column chromatography

Different type of silica gel is also available, please click here.

Selection guide

Selection flow of packing materials for normal phase preparative chromatography.

Selection guide

for reversed phase
for normal phase

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