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evitria社 offers new service - Fc-silenced antibodies

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We have recently added a new service to our list – Fc-silenced antibodies using mAbsolve’s STR technology. As we are more than happy about our service addition and the partnership with mAbsolve we want to share the news with you:

 

Fc-silenced antibodies to remove effector functions

The CH2 region of an antibody constant domain interacts with human Fc gamma receptors to activate the host’s immune system and trigger cytotoxic processes to destroy targeted cells.

 

Fc silencing involves substituting certain amino acids in the CH2 region where this initial binding occurs.

 

Other Fc-silencing technologies have had major limitations such as high levels of residual activity and restrictive licensing terms, but mAbsolve’s new STR technology overcomes these issues.

 

We are excited to add the STR technology into our antibody engineering and modification capabilities”, says our CEO, Christian Eberle.

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