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IQ Products社 末梢循環血管内皮細胞(CEC)検出キット

 循環器疾患などによる血管へのダメージを迅速に測定可能

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Special features Applications

 

Applications

 

 

Background information
Endothelial cells are cells lining the interior surface of blood vessels. Due to vascular damage, mature endothelial cells can be shed from the vessel wall and enter the circulation.
In healthy persons the absolute number of these circulating endothelial cells (CEC) in peripheral blood is very low [1,2]. Under pathological conditions, such as cardiovascular disorders, infectious diseases, immune disorders, pulmonary hypertension, sickle cell anaemia, status after organ transplantation and cancer, the absolute number of CEC in peripheral blood is significantly elevated [3-6].
Therefore, enumeration of CEC is nowadays considered as a promising tool for monitoring disease activity and assessing prognosis and response to treatment.

 

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Application
Kit contains all reagents required for rapid and reliable enumeration of circulating endothelial cells in whole blood samples according to a patented method [7].
Reagents include two specific endothelial cell markers, one marker for specific exclusion of leukocytes from the CEC gate and one marker allowing analysis of nucleated (live) cells.

 

References
1. Goon et al, Thromb. Haemost. 2006 96:45-52 2. Mancuso et al, Clin. Cancer Research 2009 15:267-73 3. Mutin et al Blood 1999 93: 2951-58 4. Mutunga et al Am. J. Respir. Crit. Care Med. 2001 163:195-200 5. Bull et al Thromb. Haemost. 2003 90: 698-703 6. Bertolini et al Nat. Rev. Cancer 2006 6: 835-45 7. Kraan et al J. Thromb. Haemost. 2012 10: 931-939 

 

 

Product Name Description Product code Package size
CEC CountTM Kit A complete kit for rapid and robust enumeration of circulating endothelial cells IQP-397 25 tests

 

 

 

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