Sino Biological社 SARS-CoV-2 Neutralizing MAbs and S2-Specific MAbs
|To support COVID-19 research, Sino Biological has developed a large collection of antibodies against different antigens of SARS-CoV-2. These antibodies can be used to detect and/or neutralize the virus in a variety of assays including ELISA, western blot, immunofluorescent staining, immunohistochemistry, SPR (Biacore and Octet), pseudovirus infection, and potentially in vivo animal studies.|
This week, Sino Biological announces the new additions to this product line:
The publication of SARS-CoV-2 antibody whitepaper.
This guidebook will help the users find the most appropriate antibodies for their assay.
The launch of two mouse mAbs with strong neutralizing activities.
These antibodies are SARS-CoV-2 specific, with no cross-reactivity with SARS-CoV, and other common coronaviruses.
The launch of a chimeric antibody specifically recognizing the S2 domain of SARS-CoV-2.
Specific and Neutralizing Antibodies against SARS-CoV-2 Spike
Neutralization Activity Assay
Neutralizing antibodies can effectively inhibit the infection of SARS-CoV-2 Spike pseudovirus on ACE2 overexpression 293T cells.
Neutralizing ability was detected by SARS-CoV-2 Inhibitor Screening ELISA Kit (Catalog# KIT001) using competitive ELISA.
These two anti-spike antibodies have been tested against all seven coronaviruses, and are shown to be specific to SARS-CoV-2 spike. The reactivity of the antibodies against the known coronaviruses is assessed in ELISA. The reactivity (OD450) is illustrated in the figures below.
Antibody Against SARS-CoV-2 Spike S2
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