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SinoBiological社 A Pleiotropic Pro-Inflammatory Cytokine


Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in innate and acquired immunity. Recent studies have implicated the IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers.
IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. In the presence of IL-2, IL-18 stimulates natural killer (NK) cells, NKT cells, and established Th1 cells to produce IL-3, IL-9, and IL-13. IL-18 similarly activates downstream signal transduction as IL-1β. IL18 binds with its receptor IL-18 receptor a (IL-18Ra). IL-18Rβ / IL-18RAcP is subsequently recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP. IL-18Ra may also bind IL-37 in association with SIGIRR to transduce an anti-inflammatory signal.
Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to support the study of the biology of IL-18.
Recombinant IL-18 Cytokines and Receptors
Sino Biological has produced high-quality recombinant IL-18 and receptor proteins from various species, such as human, mouse, cynomolgus, rhesus, rat, and canine.
• Featured IL-18 Protein
Human IL-18 Protein: 10119-HNCE
High-purity   Low-endotoxin
Tag-free   HPLC-verified
> 95 % as determined by SEC-HPLC
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Ability to induce IFN-gamma secretion by KG-1 human acute myelogenous leukemia cells in the presence of TNF-alpha Batch-to-batch Consistency
• Featured IL-18 Receptor Proteins
Mouse IL-18Ra Protein
(Cat#: 50094-M38H)
Human IL-18BP Protein
(Cat#: 10357-H08H)
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Binding Ability in a Functional ELISA, Bind to Mouse IL-18 (Cat: 50073-MNCE) Ability to Inhibit the IL-18-induced Response of KG-1 Human Acute Myelogenous Leukemia Cells
• More Related Proteins
Receptor Accessory Protein
IL-18Rβ / IL-18RAcP
Receptor Antagonist & Decoy Receptor
Antibodies for IL-18 Cytokines and Receptors
Sino Biological has developed a panel of antibodies targeting IL-18 cytokines and receptors that can be used in ELISA, WB, IF, IP, FCM, and ICC.
Anti-IL-18Rβ / IL-18RAcP Antibody
(Cat#: 10176-T24)
Anti-IL-18 Antibody
(Cat#: 310203-T44)
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Immunochemical Staining of Human IL-18Rβ in Human Colon Carcinoma Cells Immunochemical Staining of Human IL-18 in Human Lymph Node Cells
• More Related Antibodies
Anti-IL-18   Anti-IL-18Ra   Anti-IL-18Rβ   Anti-IL-18BP
Sino Biological

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