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SinoBiological社 IL-6: A Pivotal Pleiotropic Inflammatory Cytokine

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Interleukin 6 (IL-6) is a pro-inflammatory cytokine involved in immune responses, hematopoiesis, bone metabolism, and embryonic development. Elevated IL-6 is observed in patients with microbial infections and other inflammatory conditions. Targeting IL-6 has important clinical implications for diagnosing, managing, and preventing infectious diseases.
The pro-inflammatory function of IL-6 is regulated by a trans-signaling process involving soluble IL-6R (sIL-6R) and gp130 receptor. The production of sIL-6R is activated by IL-1beta and TNF-alpha. These two pro-inflammatory cytokines induce the proteolytic cleavage of IL-6R by activating ADAM10 and ADAM17.
Unlike most other soluble receptors (e.g. IL-1RA and IL-18BP), sIL-6R is NOT an inhibitor of IL-6. Instead, it activates IL-6 signaling by forming a complex with IL-6 and gp130. 10398-H08H.png
Human IL-6R (cat#: 10398-H08H) enhance the IL-6 activity on M1 mouse myeloid leukemia cells. The ED50 is typically 20-80 ng/mL.
 
Sino Biological has developed a panel of high-quality recombinant IL-6 and receptor proteins to support the study of this cytokine.
 
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Recombinant IL-6 and Receptors
Sino Biological has developed bioactive recombinant IL-6 cytokines from various species, such as human, mouse, rat, rhesus, and pig.
• Featured IL-6 Protein
Human IL-6 Protein: 10395-HNAE
 
High-purity   Low-endotoxin
 
Tag-free   HPLC-verified
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> 95 % as determined by SDS-PAGE
 
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Cell proliferation assay using TF-1 human erythroleukemic cells Batch-to-batch Consistency
• Bioactive Recombinant IL-6 from Multiple Species
Species Cat# Activity Validated
Human 10395-HNAE Bind to Human IL-6R    Cell proliferation
Mouse 50136-MNAE Cell proliferation
Rat 80076-RNAE Cell proliferation
Rhesus 90197-CNAE Cell proliferation
Sus scrofa (Pig) 62006-WNAE Bind to Human IL-6R (10398-H08H)
• Recombinant Membrane-bound IL-6 Receptor: IL-6R
IL-6 demonstrates limited cross-species bioactivity. Human IL-6 can bind to both human and mouse IL-6R, but mouse IL-6 can only bind to mouse IL-6R.
Human IL-6 Receptor
10398-H08H
  Mouse IL-6 Receptor
50280-M08H
  Rat IL-6 Receptor
81072-R08H
Canine IL-6 Receptor
70117-D08H
  Rhesus IL-6 Receptor
90324-C08H
   
• Recombinant Gp130
Gp130 is a common receptor and signal transducer shared by most IL-6 family cytokines.
Recombinant
Human gp130
  Recombinant
Mouse gp130
  Recombinant
Rat gp130
  Recombinant
Rhesus gp130
• More IL-6 Family Cytokines
IL-11   LIF   OSM   CNTF   IL-31   IL-27   NNT-1   CT-1
 
Antibodies for IL-6 and Receptors
Sino Biological has developed a comprehensive panel of antibodies targeting IL-6 cytokines and receptors, which can be used in ELISA, WB, IHC-P, and IP.
• Neutralization Antibodies: IL-6 and IL-6R
IL-6 Neutralizing Antibody
(Cat#: 10395-R508)
IL-6R Neutralizing Antibody
(Cat#: 10398-MM08)
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Neutralize IL-6 induced proliferation in the T1165 mouse plasmacytoma cells. The IC50 is typically 80-320ng/mL IL-6-dependent Inhibition of cell proliferation is neutralized by Human IL-6R neutralizing Monoclonal Antibody. The IC50 is typically 0.15-0.6 µg/mL.
 
ELISA Kits and ELISA Detection Pairs for IL-6 and Receptors
IL-6 ELISA Kit   IL-6R ELISA Kit   gp130 ELISA Kit
 
IL-6 Detection Pairs   IL-6R Detection Pairs   gp130 Detection Pairs
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