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SinoBiological社 NKG2DA: Emerging Immunotherapy Checkpoint Targets

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NKG2D/A: Emerging Immunotherapy Checkpoint Targets
NKG2D and NKG2A belong to the NKG2 (CD159) family. NKG2 proteins are predominantly expressed on cytotoxic immune cells. They are new attractive targets for the development of immune checkpoint modulators.
NKG2A is an inhibitory receptor. It forms a heterodimer with CD94 (KLRD1). CD94/NKG2A complex interacts with the non-classical MHC class I molecule HLA-E on target cells. This interaction inhibits the activation of NK cells and T cells via the tyrosine phosphatases SHP-1 or SHP-2 signaling cascades. Similar to other immune checkpoints (such as PD-1/PD-L1), CD94/NKG2A-HLA-E is also used by cancer cells to escape the immune system.
NKG2D is an activating receptor. The activation of NKG2D by its ligands, including MICA, MICB, and ULBPs (ULBP1, ULBP2, ULBP3, ULBP4, ULBP5, ULBP6) in human and H60 (a–c), RAE(α–ε) and MULT1 families in mice, is an important anti-tumor signaling axis. In mice, NKG2D uses adaptor molecules DAP10 and DAP12 to relay its signal transduction, while in human, NKG2D associates exclusively with DAP10. It can also regulate cytokine production (e.g. IL-10, IL-9, IL-13). NKG2D also plays an important role against virus infection.
 
   NKG2D/NKG2D Ligands
Sino Biological has developed high-activity NKG2D and NKG2D ligand proteins from various species to help study the NKG2D/NKG2D ligand biology.
• Binding Activity Validated by ELISA Assay
Ligands Bind with NKG2D (Cat#: 10575-H07B)
10679-H03H 15759-H02H
Human ULBP1 (Cat#: 10679-H03H) Human ULBP6 (Cat#: 15759-H02H)
 
NKG2D Binds with MICA (Cat#: 12302-H08H)
10575-H01S
MICA >95% Purity by HPLC
HPLC-12302-H08H
 
Human MICA (Cat#: HPLC-12302-H08H)
Human NKG2D (Cat#: 10575-H01S)
 
Recombinant NKG2D/NKG2D Ligands
NKG2D nkg2d MICA   MICB   ULBP1
 
ULBP2   ULBP4   ULBP6
 
   NKG2A/NKG2A Ligands
NKG2A and NKG2A ligand proteins from various species have been developed.
Human NKG2A (13905-H07H1)
Tag: His
Expressed Host: HEK293 Cells
Purity: > 90% (SDS-PAGE)
  Human NKG2A (13905-H07H1-B)
Tag: His, Biotinylated
Expressed Host: HEK293 Cells
Purity: > 85% (SDS-PAGE)
 
Mouse NKG2A (50834-M07H)
Tag: His
Expressed Host: HEK293 Cells
Purity: > 95% (SDS-PAGE)
  Human CD94 (12649-H01H)
Tag: hFc
Expressed Host: HEK293 Cells
Purity: > 95% (SDS-PAGE)
 
   NKG2 Related Antibodies
Sino Biological has developed a comprehensive panel of antibodies targeting NKG2A, NKG2D, NKG2E, MICA, MICB, ULBP1, ULBP2, which can be used in FCM, ELISA, WB, IHC, IF etc. Human MICB ELISA kit and ELISA pair set are also available.
Anti-NKG2A Antibodies
Human NKG2A (13905-T16)
Type: Rabbit PAb
Ig Type: Rabbit IgG
Application: ELISA
  Mouse NKG2A (50834-RP01)
Type: Rabbit PAb
Ig Type: Rabbit IgG
Application: ELISA
Anti-NKG2D Antibodies
Human NKG2D (10575-MM02)
Type: Mouse MAb
Ig Type: Mouse IgG3
Application: ELISA
  Human NKG2D (10575-T16)
Type: Rabbit PAb
Ig Type: Rabbit IgG
Application: ELISA
NKG2 Ligands Related Antibodies
MICA
 
12302-MM04
(ELISA, FCM)
  12302-MM04-P
(FCM)
  12302-MM04-A
(FCM)
 
MICB
 
10759-MM12
(ELISA, FCM)
  10759-MM12-A
(FCM)
  10759-R102
(WB)
 
ULBP2
 
12143-R022
(IHC-P)
  12143-RP02
(ELISA, IHC-P)
  12143-T16
(ELISA)
 
ULBP1
 
201510-T10
(IHC-P, ICC/IF)

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