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SinoBiological社 Recombinant SARS-CoV-2 Omicron (B.1.1.529) Variants

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Mutations in the Spike Glycoprotein of Omicron

The Omicron variant is by far the most divergent variant characterized by a high number of mutations in the spike protein. Several mutations (e.g., N501Y, P681H) have been identified in previous variants and are associated with increased transmissibility, immune escape, or other properties.

• 30 amino acid changes: among which 15 are located in the RBD region
• Three deletions
• Three insertions in the spike protein NTD

Mutations_in_the_Spike_Glycoprotein_of_Omicron.pngSino Biological is developing a series of recombinant Omicron Spike Proteins to support the study of Omicron variant.

Please contact us for more detailed information. 

Cat#

 

Molecules

Host

Tag

Mutants

40592-V08H121

 

RBD

HEK293

C-His

G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H

40592-V49H7

RBD

HEK293

C-His-AVI

G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H

40592-V49H7-B

RBD

HEK293

C-His-AVI

G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H

40591-V08H41

S1

HEK293

C-His

A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H

40589-V08H26

S-ECD Trimer 

HEK293

C-His

A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F

40589-V49H3-B

S-ECD Trimer 

HEK293

C-His-AVI

A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F

40589-V08B33

S-ECD

Insect

C-His

A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F

40588-V07E34

N

E.coli

N-His

P13L, E31del, R32del, S33del, R203K, G204R

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