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SinoBiological社 VEGFs and Receptors: Key Mediators in Vascular and Nervous Systems

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Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with mitogenic and angiogenic activities. The importance of VEGFs and receptors in angiogenesis, tumorigenesis, and neuroprotection makes them attractive targets for drug development.
The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF bind in specific patterns to three related receptor protein tyrosine kinases, VEGFR1/FLT1, VEGFR2/KDR, and VEGFR3/FLT4, and two non-tyrosine kinase transmembrane proteins, neuropilin-1 (NRP1) and neuropilin-2 (NRP2). The ligand-receptor binding induces the formation of homo- and heteromeric receptor complexes and activates downstream signaling. In addition to VEGF signaling, neuropilins also act as co-receptors to numerous other signaling pathways, including those triggered by Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet-Derived Growth Factor (PDGF) and Transforming Growth Factor beta (TGFβ).

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(日本時間 9月16日(木) 午前4時)

VEGF Family Ligands and Receptors
Sino Biological has over 65 recombinant VEGF & receptor proteins covering all VEGF family members and several isoforms of VEGF. A vast majority of these recombinant proteins were expressed in eukaryotic cells (human cells or insect cells), which ensures proper modification and higher activity of proteins.
• High Activity
Human / Cynomolgus VEGF165
(Cat#: 11066-HNAH)
Human KDR
(Cat#: 10012-H08H)
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Cell proliferation assay using human umbilical vein endothelial cells (HUVEC) Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC)
• Recommended Recombinant VEGF & Receptor Proteins
Cat# Molecule Species Activity Tag
10136-H02H VEGFR1/FLT-1 Human Active hFc
10136-H08H VEGFR1/FLT-1 Human Active His
10136-H08H1 VEGFR1/FLT-1 Human Active His
10806-H02H VEGFR3/FLT4 (ECD) Human Active hFc
50584-M02H VEGFR3/FLT-4 Mouse Active hFc
10012-H02H VEGFR2/KDR Human Active hFc
10012-H02H1 VEGFR2/KDR (Domain 1&2&3) Human Active hFc
10012-H02H1-B VEGFR2/KDR (Domain 1&2&3) Human   hFc
10012-H02H2 VEGFR2/KDR (Domain 2&3) Human Active hFc
10012-H08H2 VEGFR2/KDR (Domain 2&3) Human   His
10012-H20B1 VEGFR2/KDR Human Active GST & His
50998-M08H-B VEGFR2/KDR Mouse Active His
80113-R02H VEGFR2/KDR Rat Active hFc
80113-R08H VEGFR2/KDR Rat   His
90907-C08H VEGFR2/KDR Cynomolgus   His
10011-H08H NRP1 Human Active His
10695-H02H NRP2 Human Active hFc
11066-HNAB-B VEGF165 Human, Cynomolgus   Native
11066-HNAH VEGF165 Human, Cynomolgus Active Native
63004-ZNAB VEGF165 Danio rerio (zebrafish) Active Native
70004-DNAH VEGF164 Canine Active Native
80006-RNAB VEGF164 Rat Active Native
10544-H01H VEGFB Human Active hFc
80103-R01H VEGFC (aa 108-223) Mouse, Rat Active hFc
80103-R08H VEGFC (aa 108-223) Mouse, Rat Active His
50157-M01H VEGFD Mouse Active hFc
50157-M08H VEGFD Mouse Active His
80104-R01H VEGFD Rat Active hFc
10274-H05H PIGF Human Active mFc
• More Recombinant VEGF & Receptor Proteins
VEGFA   VEGFB   VEGFC   VEGFD   PIGF
 
VEGFR1/FLT-1   VEGFR2/KDR VEGFR3/FLT-4   NRP1   NRP2
 
VEGF/VEGFR Antibodies
Sino Biological has over 100 antibodies against VEGF & receptor proteins with validated activities in various applications, including western blotting, ELISA, immunohistochemistry, immunofluorescence, flow cytometry, and neutralization. ELISA kits and ELISA pair sets are also available.
• Antibody List of CSFs and CSFR
Anti-VEGFA   Anti-VEGFC   Anti-VEGFD
 
Anti-PIGF   Anti-VEGFR1/FLT-1   Anti-VEGFR2/KDR
 
Anti-VEGFR3/FLT-4   Anti-NRP1   Anti-NRP2

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