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TriLink BioTechnologies社 Top Nucleic Acid Research Highlights: Advancements You Can't Miss




Research news

Lipid nanoparticle-mRNA for base editing of congenital brain disease

Genetic central nervous system (CNS) diseases often begin before birth, causing significant morbidity by the time of birth. Prenatal DNA sequencing allows early identification and treatment using mRNA-based gene editing tools like CRISPR-Cas9. In utero, gene editing can maximize therapeutic doses and utilize the tolerant fetal immune system.

In this blog, we explore the development of lipid nanoparticles (LNPs) for delivering mRNA base-editing platforms to fetal mouse and monkey brains, demonstrating brain-cell selectivity and efficient gene modulation.

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In other research news 

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Multi-factor genome editing offers improved outcomes for HIV-1 treament

A cure for HIV could be one step closer with the development of a targeted genome editing strategy for autologous hematopoietic stem and progenitor cell transplantation. Learn how TriLink’s sgRNA facilitated this work in our latest Research Spotlight.

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A universal STING mimic boosts anti-tumor immunity

The blog discusses a new STING mimic called uniSTING, which activates tumor control pathways independently of endogenous STING expression, showing promising anti-tumor efficacy in vivo when delivered via CleanCap® mRNA encapsulated into lipid nanoparticles.

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Our latest advancements

Discover new tools and products


TriLink is excited to start offering rNTPs with ≥99% purity in both research-use-only (RUO) and good manufacturing practice (GMP) grades, enabling you to seamlessly transition from research and discovery to clinical development.

Providing confidence in RNA manufacturing, our rNTPs are designed for:

  • Quality — Built phase appropriately with orthogonal analytical methods for therapeutic and diagnostic development, from discovery to commercialization
  • Reliability — Batch-to-batch quality consistency stemming from >25 years of nucleic acid innovation, expertise, and manufacturing
  • Versatility — Catalog sizes, custom aliquots, bulk offerings, and special packaging to suit diverse applications

Discover rNTP offerings ➔ 

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