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Sino Biological社 Most concerned mutation of new SARS-CoV-2 Variant in U.K.

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Most_concerned_mutation_of_new_SARS-CoV-2_Variant_in_U.K._1.jpg
A distinct strain of SARS-CoV-2 emerges in the UK recently, reportedly accounting for over 60% new infections in the London area. CDC also names the variant "SARS-CoV-2 VOC (variant of concern) 202012/01", highlighting its clinical significance. Most_concerned_mutation_of_new_SARS-CoV-2_Variant_in_U.K._2.jpg

The newly identified lineage B.1.1.7 carries an unusually high number of genetic mutations, resulting in an unprecedented 14 AA replacement. Eight of these mutations occur in the spike protein and the following three are particularly worrisome.
-- N501Y, which reportedly leads to an increased binding affinity to human and murine ACE2 receptors
-- 69-70del, which arose from the outbreak linked to farmed minks
-- P681H, which is closed to the furin cleavage site.

It's also important to monitor the B.1.1.7 strain together with the previously identified high frequency variants, such as
-- D614G, which may cause a moderately increased transmissibility
-- N439K, which may be an "escape mutant" for some neutralizing antibodies
-- Y453F, which may be an "escape mutant" for some neutralizing antibodies.

Sino Biological has produced a collection of recombinant antigens for these variants. The reagents can be used to evaluate the efficacy of the antibodies and vaccination.
Priority Mutations Being Tracked

N501Y

 

Y453F

 

D614G

 

N439K

Most_concerned_mutation_of_new_SARS-CoV-2_Variant_in_U.K._3.png Recombinant Spike N501Y Mutant

Cat#: 40592-V08H82

Activity: Bind with ACE2
Full List of SARS-CoV-2 Spike Mutants

P337S

F338L

V341I

F342L

A344S

 

A348S

N354D

A352S

S359N

V367F

 

N370S

A372T

A372S

F377L

K378N

 

K378R

P384L

T385A

T393P

V395I

 

E406Q

R408I

Q409E

Q414R

Q414E

 

K417N

A435S

W436R

N439K  

N440K

 

K444R

V445F

G446V

G446S

L452R

 

Y453F  

F456L

F456E

K458R

K458Q

 

E471Q

I472V

G476S

S477R

S477I

 

S477N

T478I

P479S

N481D

G482S

 

V483A

V483I

G485S

F486S

F490S

 

S494P

P499R

N501Y  

V503F

Y505C

 

Y508H

A520V

A520S

P521S

P521R

 

A522V

A522S

D614G  

D405V, Q414A

 

R683A, R685A, F817P, A892P, A899P,   A942P, K986P, V987P

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