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Sino Biological社 SARS-CoV-2 Y453F Mink Mutation

SARS-CoV-2_Y453F_Mink_Mutation_1.jpg
An unprecedented mink cull has been ordered in Denmark amid the outbreak of SARS-CoV-2 in these farmed animals. The plan was announced after scientists discovered a widespread Y453F mutation in the spike protein, that has been passed from animal to humans. SARS-CoV-2_Y453F_Mink_Mutation_2.png
This mutation is of particular concern, because it occurs at a conservative domain of the receptor
binding domain (RBD) directly involved in ACE2 binding. Results from some preliminary studies suggest the Y453F mutation affects the ability of the Spike protein to bind with ACE2, while others demonstrate that the mutated spike can escape from detection from a commercial anti-S antibody.
Although there is still no clear evidence indicating this mutation, or any other mutation like the
popular D614G, has any clinical significance, the characteristics of the mutations need to be
thoroughly investigated in the context of vaccine and antibody therapy.
Sino Biological has launched the recombinant Y453F RBD protein. This product is the newest addition to a large library of recombinant spike variants (full list here). These proteins can be used to evaluate the efficacy of the antibodies and vaccination.
Full List of SARS-CoV-2 Spike Mutants

P337S

 

F338L

 

V341I

 

F342L

 

A344S

 

A348S

 

N354D

 

A352S

 

S359N

 

V367F

 

N370S

 

A372T

 

A372S

 

F377L

 

K378N

 

K378R

 

P384L

 

T385A

 

T393P

 

V395I

 

E406Q

 

R408I

 

Q409E

 

Q414R

 

Q414E

 

K417N

 

A435S

 

W436R

 

N439K

 

N440K

 

K444R

 

V445F

 

G446V

 

G446S

 

L452R

 

Y453F

 

F456L

 

F456E

 

K458R

 

K458Q

 

E471Q

 

I472V

 

G476S

 

S477R

 

S477I

 

S477N

 

T478I

 

P479S

 

N481D

 

G482S

 

V483A

 

V483I

 

G485S

 

F486S

 

F490S

 

S494P

 

P499R

 

V503F

 

Y505C

 

Y508H

 

A520V

 

A520S

 

P521S

 

P521R

 

A522V

 

A522S

 

D614G

 

D405V, Q414A

 

R683A, R685A, F817P, A892P, A899P,   A942P, K986P, V987P

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