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Sino Biological社 Spike D614G variant enables SARS-CoV-2 to be more transmissive

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SARS-CoV-2 Spike S1 Variant

D614G

Genomic mutations drive the evolution of all viruses. The mutations enable the virus to:
1, Escape from the immune response;
2, Acquire a selective advantage in transmission.
A recent study from Los Alamos National Laboratory has identified a major mutation on SARS-CoV-2 Spike initially emerged in European countries. This D614G mutation has rapidly become dominant in these regions, suggesting this mutation may make the SARS-CoV-2 virus more transmissive. It's critical to understand the biology of this variant, particularly in the context of vaccine and drug design.

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D614G_mutation_(40591-V08H3)_figure.jpg Sino Biological has developed a recombinant S1 protein with a D614G mutation (40591-V08H3).

The recombinant 614G variant demonstrated comparable ACE2 binding as the original 614D, as evidenced in our ELISA analyses. This is consistent with the fact that the mutation is outside of the RBD domain.
SARS-CoV-2 Spike Variants


In addition to the D614G mutation, several other mutations are also identified. Some of them are believed to enhance S1's ability to bind with ACE2. Sino Biological has developed a panel of mutated Spike proteins to facilitate the study of these variants.

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S1

D614G
[ His, Expressed in HEK293 cell ]

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RBD

V367F
[ His, Expressed in HEK293 cell ]

V367F
[ mFc, Expressed in HEK293 cell ]

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RBD

V483A
[ His, Expressed in HEK293 cell ]

A435S
[ His, Expressed in HEK293 cell ]

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RBD

N354D
[ His, Expressed in HEK293 cell ]

F342L
[ His, Expressed in HEK293 cell ]

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RBD

G476S
[ His, Expressed in HEK293 cell ]

K458R
[ His, Expressed in HEK293 cell ]

Full List of SARS-CoV-2 Antigens

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