幹細胞研究用低分子化合物
Tocris Bioscience 社（以下 Tocris 社）は、再生医療研究の分野における低分子化合物製造のリーディングカンパニーです。 豊富なラインアップはもちろんのこと、研究から臨床までサポートできるよう、3 種類のグレードを用意しています。
キャンペーン実施中！
Tocris 社では、幹細胞に関連する冊子を用意しており、掲載の低分子化合物を特別価格で提供中です。
Tocris 社では、幹細胞に関連する冊子を用意しており、掲載の低分子化合物を特別価格で提供中です。
- 幹細胞研究用低分子化合物
（Small Molecules for Stem Cell Research） - 神経幹細胞
（Neural Stem Cell）
製品説明
幅広いラインアップ
iPS / ES 細胞の初期化・未分化維持・分化に関係する、さまざまなシグナル伝達に作用する低分子化合物を提供しています。汎用的に使用する一般的な化合物から、ライセンスを受けて販売するユニークな化合物まで、豊富に取りそろえています。
Tocris 社では、研究者の皆さまが自信を持って実験成果を発表できるよう、徹底した品質管理に取り組んでいます。経験豊富な分析チームは、最終製品に不要な不純物が含まれていないよう、高純度（≧98 %）の化合物をお届けするとともに、ほかのサプライヤーでは実施されていない広範な分析を行っています。
基礎研究から臨床試験までサポート
Tocris 社では、3 種類のグレードを用意しており、臨床試験までをサポートできるよう、研究の初期段階での使用にお薦めの Standard Catalog（RUO）、よりステップが進んだ段階で使用いただける Ancillary Material（AM）/ Good Manufacturing Practice（GMP） を用意しています。これらは全て、ISO 9001:2015 準拠の製造拠点にて化学合成された高純度な製品となっています。
- 化合物をお探しの際は、ぜひ Tocris 社 Web サイト にアクセスください。Web サイトは親切に設計されており、目的化合物が見つけやすく、製品情報も充実しています。
- Tocris 社 Web サイトで検索した化合物の価格などは、弊社のオンラインカタログ e-Nacalai Search Version でご覧いただけます。
Tocris Bioscience 社 Web サイト紹介
Tocris Bioscience 社（以下 Tocris 社）では、さまざまな角度から製品を分類しており、豊富なラインアップの中、目的化合物が見つけやすくなっています。ぜひ Tocris 社 Web サイト をご覧ください。
トップページの Products へカーソルを合わせると、PHARMACOLOGY、CELL BIOLOGY、PRODUCT TYPE、RESEARCH AREA の 4 つに項目が分けられています。
例えば iPS/ES 細胞研究用の化合物は、CELL BIOLOGY の中にある、Stem Cells から見つけられます。
価格表
リプログラミング
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| (+/-)-Bay K 8644 | CaV1.x activator; promotes generation of iPSCs from MEFs | 1544 |  |
| 5-BrdU | Synthetic thymidine analog; replaces Oct-4 in transcription factor-mediated reprogramming | 5015 | |
| BIRB 796 | High affinity and selective p38 kinase inhibitor ; used in protocols to generate iPSCs | 5989 | |
| CHIR 98014 | Highly potent and selective GSK-3β inhibitor; used in differentiation and reprogramming of stem cells | 6695 | |
| CHIR 99021 | Highly selective GSK-3β inhibitor; used in small molecule cocktail to generate ciPSCs from MEFs | 4423 | |
| DBZ | γ-secretase inhibitor; inhibits Notch pathway; promotes formation of iPSCs | 4489 | |
| 3-Deazaneplanocin A hydrochloride | EZH2 histone methyltransferase inhibitor; widely used in chemical reprogramming protocols as it promotes expression of Oct4 in iPSCs | 4703 | |
| (S)-(+)-Dimethindene maleate | Selective ACh muscarinic M2 antagonist; used in generation of extended pluripotent stem (EPS) cells | 1425 | |
| Kenpaullone | GSK-3β inhibitor; also inhibits cdks; promotes generation of iPSCs from somatic cells | 1398 | |
| Linifanib | Potent receptor tyrosine kinase (RTK) inhibitor; promotes the generation and reprogramming of iPSCs from somatic cells | 7743 | |
| Minocycline hydrochloride | Antibiotic; allows formation of extended pluripotent stem (EPS) cells | 3268 | |
| Neurodazine | Induces neurogenesis in mature skeletal muscle cells | 3656 | |
| O4I2 | Oct3/4 inducer; induces expression of pluripotency-associated genes | 5664 | |
| PD 0325901 | Potent inhibitor of MEK1/2; enhances generation of iPSCs | 4192 | |
| RepSox | Potent and selective inhibitor of TGF-βRI; enhances reprogramming efficiency | 3742 | |
| RG 108 | Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation | 3295 | |
| SB 431542 | Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7; replaces SOX2 in reprogramming of fibroblasts into iPSCs | 1614 | |
| SB 590885 | Potent B-Raf inhibitor; used in a protocol to reprogram HEFs into iPSCs | 2650 | |
| SGC-CBP30 | Potent CBP/p300 BRD inhibitor; used in protocols to generate iPSCs | 4889 | |
| SMER 28 | Positive regulator of autophagy; promotes reprogramming of fibroblasts to neural stem-like cells | 4297 | |
| Trichostatin A | Potent histone deacetylase inhibitor; accelerates reprogramming of primordial germ cells to PSCs | 1406 | |
| TTNPB | Retinoic acid analog; RAR agonist; enhances efficiency of reprogramming in ciPSCs | 0761 | |
| UNC 0224 | Potent G9a and GLP inhibitor; used in a protocol to reprogram HEFs into iPSCs | 3861 | |
| Valproic acid, sodium salt | Histone deacetylase inhibitor; enhances efficiency of reprogramming of somatic cells | 2815 | |
自己複製能・多能性維持（CEPT Cocktail）
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| Chroman 1 | Highly potent and selective ROCK inhibitor; maintains survival of hPSCs | 7163 | |
| Emricasan | Potent pan-caspase inhibitor; promotes survival of hPSCs | 7310 | |
| Polyamine Supplement x1000 (lyophilized) | Media supplement to boost cell growth; component of CEPT cocktail to enhance stem cell viability | 7739 | |
| trans-ISRIB | Integrated stress response (ISR) inhibitor; promotes survival of hPSCs | 5284 | |
| CEPT Cocktail Kit | Cell culture supplement for improving stem cell survival | 7991 | |
自己複製能・多能性維持
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| A 769662 | Potent AMPK activator; inhibits MSC proliferation | 3336 | |
| A 77-01 | Potent inhibitor of TGF-βRI; likely active metabolite of A 83-01 (Cat. No. 2939) | 6712 | |
| A 83-01 | Selective inhibitor of TGF-βRI, ALK4 and ALK7; maintains self- renewal of human iPSCs | 2939 | |
| AS 1842856 | Potent and selective Foxo1 inhibitor; suppresses differentiation of adipocytes | 4265 | |
| BIO | Potent GSK-3β inhibitor; also inhibits cdks; maintains self-renewal and pluripotency of ESCs | 3194 | |
| CDK8/19i | Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture | 7372 | |
| DMSO, Cell Cryopreserve Grade | Intracellular cryoprotective agent | 7726 | |
| INDY | DYRK1A/B inhibitor; impairs self-renewal of NSCs | 4997 | |
| LY 294002 hydrochloride | Prototypical PI 3-kinase inhibitor; also inhibits other kinases; suppresses proliferation of mESCs | 1130 | |
| PD 173074 | FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors | 3044 | |
| PD 98059 | MEK inhibitor; enhances ESC self-renewal | 1213 | |
| Pioglitazone hydrochloride | Acts synergistically with Y-27632 (Cat. No. 1254) to improve PSC cloning efficiency; PPARγ agonist | 4124 | |
| EHNA hydrochloride | Adenosine deaminase inhibitor; suppresses spontaneous differentiation of human ESCs | 1261 | |
| Go 6983 | Broad spectrum PKC inhibitor; optimizes naïve human pluripotent stem cell growth and viability | 2285 | |
| Epiblastin A | CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal | 6340 | |
| FzM1.8 | Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness | 6961 | |
| SB 202190 | Potent, selective inhibitor of p38 MAPK; promotes stability of human PSCs | 1264 | |
| SB 203580 | Selective inhibitor of p38 MAPK; stimulates neural stem cell proliferation | 1202 | |
| SB 216763 | Potent, selective GSK-3β inhibitor; maintains pluripotency of mouse ESCs | 1616 | |
| SP 600125 | Selective JNK inhibitor; used for maintaining stem cells in naive pluripotent state | 1496 | |
| SR 3677 dihydrochloride | Potent, selective Rho-kinase (ROCK) inhibitor | 3667 | |
| SU 5402 | Potent FGFR and VEGFR inhibitor; supports mESC self-renewal | 3300 | |
| Surfen | Heparin sulfate antagonist; maintains pluripotency of hESCs | 6634 | |
| U0126 | Potent, selective inhibitor of MEK1 and 2; maintains hPSCs self-renewal | 1144 | |
| WH-4-023 | Potent and selective Lck and Src inhibitor; also inhibits SIK; supports self-renewal of naive hESCs | 5413 | |
| Y-27632 dihydrochloride | Selective ROCK inhibitor; increases survival of human embryonic stem cells undergoing cryopreservation | 1254 | |
| Yhhu 3792 | Notch signaling pathway activator; enhances the self-renewal capability of NSCs | 6599 | |
分化
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| β細胞 | |||
| Compound E | Used in the generation of β cells from hPSCs ; γ-secretase inhibitor | 6476 | |
| ISX 9 | Used in protocols to generate β cells | 4439 | |
| RepSox | Used in protocols to generate β cells from hPSCs; TGF-βRI inhibitor | 3742 | |
| SANT-1 | Used in protocols to generate β cells from hPSCs; TGF-βRI inhibitor; inhibits Hedgehog signaling | 1974 | |
| TPPB | Induces differentiation of hESCs into pancreatic progenitors; PKC activator | 5343 | |
| T3 | Used in generation of β cells | 6666 | |
| 心筋細胞 | |||
| 5-Azacytidine | DNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes | 3842 | |
| Dorsomorphin dihydrochloride | Potent AMPK inhibitor; also BMP type I receptor inhibitor; promotes cardiomyocyte differentiation in mouse ESCs | 3093 | |
| 1-EBIO | Activator of epithelial KCa channels; promotes differentiation of ESCs to cardiomyocytes | 1041 | |
| ISX 9 | Induces cardiomyogenic differentiation; neurogenic agent; induces neuronal differentiation of SVZ progenitors | 4439 | |
| IWP 2 | PORCN inhibitor; inhibits Wnt processing and secretion; suppresses self-renewal in R1 ESCs and promotes cardiomyocyte differentiation | 3533 | |
| IWP 4 | Potent inhibitor of Wnt/β-catenin signaling; induces cardiomyocyte differentiation of human ESCs and iPSCs | 5214 | |
| JNJ 10198409 | Potent PDGFRα and PDGFRβ inhibitor; enhances transdifferentiation of human fibroblasts into functional cardiomyocytes, as part of 9C cocktail | 6976 | |
| Poly(I:C) | TLR3 agonist; promotes maturation of hPSC-derived cardiomyocytes | 4287 | |
| Pyridone 6 | Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable | 6577 | |
| SU 16f | Potent and selective PDGFRβ inhibitor; component of 9C cocktail for conversion of fibroblasts to cardiomyocytes | 3304 | |
| T3 | Thyroid hormone; promotes differentiation and maturation of hPSC-derived cardiomyocytes | 6666 | |
| T 112 | Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes | 7690 | |
| XAV 939 | Potent tankyrase inhibitor; promotes cardiomyogenesis | 3748 | |
| Zebularine | DNA methyltransferase and cytidine deaminase inhibitor; induces cardiomyocyte differentiation in MSCs | 2293 | |
| 肝細胞 | |||
| Sodium butyrate | Histone deacetylase inhibitor; directs differentiation of mESCs into hepatocytes | 3850 | |
| 間葉系幹細胞 | |||
| 2-Phospho-L-ascorbic acid trisodium salt | Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs | 5778 | |
| AICAR | AMPK activator; promotes osteogenic differentiation of bone marrow-derived MSCs | 2840 | |
| Dexamethasone | Anti-inflammatory glucocorticoid; induces differentiation of human MSCs | 1126 | |
| Kartogenin | Potently induces chondrogenesis in MSCs | 4513 | |
| KI-7 | Positive allosteric modulator of A2B receptors; potentiates osteoblast differentiation from MSCs | 6787 | |
| Nicotinamide | PARP-1 inhibitor; promotes MSC differentiation | 4106 | |
| Purmorphamine | Smo receptor agonist | 4551 | |
| SK 216 | Plasminogen activator inhibitor-1 (PAI-1) inhibitor; attenuates TGF-β-dependent epithelial-mesenchymal transition | 6187 | |
| 神経細胞 | |||
| Compound E | γ-secretase inhibitor; induces neuronal differentiation | 6476 | |
| DAPT | γ-secretase inhibitor; induces neuronal differentiation | 2634 | |
| Dibutyryl-cAMP, sodium salt | Cell-permeable cAMP analog; promotes differentiation of hPSCs to dopaminergic neurons | 1141 | |
| EC 23 | Synthetic retinoid; induces neural differentiation of stem cells | 4011 | |
| Fluoxetine hydrochloride | 5-HT reuptake inhibitor; induces differentiation of neuronal precursors | 0927 | |
| Forskolin | Adenylyl cyclase activator; induces neuronal differentiation | 1099 | |
| Hh-Ag1.5 | Potent and high affinity Smo receptor agonist; induces differentiation of PSCs into spinal motor and sensory neurons | 7807 | |
| IBMX | PDE inhibitor (non-selective); facilitates differentiation of neural progenitor cells | 2845 | |
| ISX 9 | Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation | 4439 | |
| KHS 101 hydrochloride | Selective inducer of neuronal differentiation in hippocampal neural progenitors | 4888 | |
| LDN 193189 dihydrochloride | Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs | 6053 | |
| Metformin hydrochloride | Activator of LKB1/AMPK; enhances neurogenesis; antidiabetic agent | 2864 | |
| ML 184 | Selective GPR55 agonist; also promotes NSC proliferation and differentiation | 6668 | |
| 1-Oleoyl lysophosphatidic acid sodium salt | Endogenous agonist of LPA1 and LPA2; inhibits differentiation of neural stem cells into neurons | 3854 | |
| P7C3 | NAMPT activator; also proneurogenic and neuroprotective | 4076 | |
| PD 173074 | FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors | 3044 | |
| PNU 74654 | β-catenin binder; inhibits Wnt signaling; promotes neural differentiation of hPSCs as part of a chemical cocktail | 3534 | |
| SAG | Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway; enhances neuronal differentiation of iPSCs into dopaminergic neurons | 4366 | |
| SAG dihydrochloride | Dihydrochloride salt of SAG | 6390 | |
| SB 431542 | Promotes neural differentiation of hPSCs; inhibitor of TGF-βRI, ALK4 and ALK7 | 1614 | |
| TWS 119 | GSK-3β inhibitor; induces neuronal differentiation in ESCs; | 7405 | |
| 骨細胞 | |||
| CW 008 | PKA signaling activator; promotes osteogenesis from hMSCs | 5495 | |
| 網膜 | |||
| CKI 7 dihydrochloride | CK1 inhibitor; induces retinal cell differentiation from human ESCs and iPSCs | 5329 | |
| EC 23 | Synthetic retinoid; induces neural differentiation of hESCs | 4011 | |
| Retinoic acid | Promotes maturation of retinal organoids; retinoic acid receptor agonist | 0695 | |
| その他 | |||
| Clemastine fumarate | H1 antagonist; promotes differentiation of oligodendrocytes from progenitors | 1453 | |
| FM19G11 | HIF α-subunit inhibitor; inhibits transcriptional activity of pluripotency markers | 6653 | |
| Ketoconazole | Cytochrome P450c17 inhibitor; promotes differentiation of oligodendrocytes from progenitors | 1103 | |
| NNMTi | Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation | 6900 | |
| PluriSln 1 | SCD-1 inhibitor; selectively eliminates undifferentiated hPSCs from culture | 4847 | |
| Rosiglitazone | Potent and selective PPARγ agonist; promotes differentiation of adipocytes | 5325 | |
| SIS3 | Selective Smad3 inhibitor; inhibits TGF-βRI signaling and inhibits TGF-β-induced myofibroblast differentiation | 5291 | |
| TPPB | High affinity PKC activator; induces differentiation of hESC to pancreatic progenitors | 5343 | |
造血幹細胞
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| N-Acetylcysteine amide | GSH precursor; antioxidant; maintains HSC function in culture | 5619 | |
| Alexidine dihydrochloride | Inhibitor of PTPMT1; preserves functional hematopoietic stem cells ex vivo | 3979 | |
| AMD 3100 octahydrochloride | Promotes HSCs mobilization and expansion | 3299 | |
| BIO 5192 | Highly potent and selective inhibitor of integrin 41 (VLA-4); promotes HSCs and progenitor mobilization | 5051 | |
| BOP | α9β1/α4β1 integrin inhibitor; promotes HSCs mobilization | 6047 | |
| BOP-JF646 | Red fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor 646; fluorogenic; photostable | 6997 | |
| CASIN | Cdc42 inhibitor; induces HSC mobilization; restores cell polarity | 5050 | |
| CH 223191 | Potent aryl hydrocarbon receptor (AhR) antagonist, HSC expansion in vitro | 3858 | |
| CPI 203 | BET Bromodomain inhibitor; promotes HSC expansion | 5331 | |
| 16,16-Dimethyl Prostaglandin E2 | Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development | 4027 | |
| DiD perchlorate | HSC stain; lipophilic fluorescent reagent | 5702 | |
| Diprotin A | Dipeptidyl peptidase IV (DPP-IV) inhibitor; enhances HSCs viability after harvesting | 6019 | |
| FICZ | Aryl hydrocarbon receptor (AhR) agonist; facilitates hPSC to HSC manufacture in vitro | 5304 | |
| GW 9662 | PPARγ antagonist; promotes HSCs expansion; increases HSCs engraftment | 1508 | |
| MB 05032 | Potent FBPase inhibitor; promotes HSC expansion | 6618 | |
| Nicotinamide | PARP1 inhibitor; promotes proliferation and expansion of HSC in vitro | 4106 | |
| Prostaglandin E2 | endogenous prostaglandin; promotes HSCs expansion; increases HSCs engraftment | 2296 | |
| Sildenafil citrate | Promotes HSCs mobilization | 3784 | |
| Troglitazone | Selective PPARγ agonist; antidiabetic agent; inhibits cell growth of hematopoietic cell lines | 3114 | |
オルガノイド
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| A 83-01 | Selective inhibitor of TGF-βRI, ALK4 and ALK7; 3D growth matrix component and additive for long-term organoid growth | 2939 | |
| CHIR 99021 | Highly selective GSK-3β inhibitor; commonly used in organoid generation | 4423 | |
| DAPT | g-secretase inhibitor; induces neuronal differentiation; 3D Growth matrix component | 2634 | |
| endo-IWR 1 | Wnt/-β-Catenin signaling inhibitor; axin stabilizer; component of neocortex differentiation media | 3532 | |
| Forskolin | Adenylyl cyclase activator; used in liver organoid generation | 1099 | |
| Galunisertib | ALK4 and ALK5 (TGFβRI) inhibitor; component of growth media for urothelial organoids | 6956 | |
| Heparin sodium salt | Used in protocol to generate kidney organoids | 2812 | |
| IWP 2 | PORCN inhibitor; inhibits Wnt processing and secretion; component of heart organoid differentiation media | 3533 | |
| IWP 4 | Potent inhibitor of Wnt/β-catenin signaling; component of heart organoid differentiation media | 5214 | |
| LDN 193189 dihydrochloride | Potent and selective ALK2 and ALK3 inhibitor; component of brain organoid differentiation media | 6053 | |
| Nicotinamide | PARP-1 inhibitor; commonly used as 3D growth matrix component | 4106 | |
| N-Acetylcysteine | Used in organoid media; glutathione (GSH) precursor | 7874 | |
| PD 0325901 | Potent inhibitor of MEK1/2; base media component | 4192 | |
| Prostaglandin E2 | Major endogenous prostanoid; 3D growth matrix component used in liver and prostate organoid generation | 2296 | |
| Retinoic acid | Endogenous retinoic acid receptor agonist; 3D growth matrix component used in organoid generation | 0695 | |
| SB 202190 | Potent, selective inhibitor of p38 MAPK; 3D growth matrix component used in organoid generation | 1264 | |
| SB 431542 | Potent selective inhibitor of TGF-βRI, ALK4 and ALK7; 3D growth matrix component used in organoid generation | 1614 | |
| Y-27632 dihydrochloride | Selective ROCK inhibitor; 3D growth matrix component used in organoid generation | 1254 | |
Ancillary Material Grade
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| A 83-01 | A 83-01 synthesized to Ancillary Material Grade | TB2939-RMU | |
| L-Ascorbic acid | L-Ascorbic acid synthesized to Ancillary Material Grade | TB4055-RMU | |
| DAPT | DAPT synthesized to Ancillary Material Grade | TB2634-RMU | |
| Dexamethasone | Dexamethasone synthesized to Ancillary Material Grade | TB1126-RMU | |
| DZNep HCl | DZNep synthesized to Ancillary Material Grade | TB4703-RMU | |
| endo-IWR 1 | endo-IWR 1 synthesized to Ancillary Material Grade | TB3532-RMU | |
| Forskolin | Forskolin synthesized to Ancillary Material Grade | TB1099-RMU | |
| Nicotinamide | Nicotinamide synthesized to Ancillary Material Grade | TB4106-RMU | |
| RepSox | RepSox synthesized to Ancillary Material Grade | TB3742-RMU | |
| Retinoic acid | Retinoic acid synthesized to Ancillary Material Grade | TB0695-RMU | |
| Staurosporine | Staurosporine synthesized to Ancillary Material Grade | TB1285-RMU | |
| T3 | T3 synthesized to Ancillary Material Grade | TB6666-RMU | |
| TCS JNK 6o | TCS JNK 6o synthesized to Ancillary Material Grade | TB3222-RMU | |
GMP Grade
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| CHIR 99021 | CHIR 99021 synthesized to cGMP guidelines | TB4423-GMP | |
| LDN 193189 | LDN 193189 synthesized to cGMP guidelines | TB6053-GMP | |
| SB 431542 | SB 431542 synthesized to cGMP guidelines | TB1614-GMP | |
| XAV 939 | XAV 939 synthesized to cGMP guidelines | TB3748-GMP | |
| Y-27632 dihydrochloride | Y-27632 synthesized to cGMP guidelines | TB1254-GMP | |
エピジェネティクス
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| ブロモドメイン | |||
| (+)-JQ1 | Potent and selective BET bromodomain inhibitor; cell permeable; promotes reprogramming of fibroblasts | 4499 | |
| (-)-JQ1 | Negative control for (+)-JQ1 | 5603 | |
| CPI 203 | BET bromodomain inhibitor; arrests cell cycle at G1 phase; promotes reprogramming of fibroblasts to hiPSCs | 5331 | |
| I-BET 151 dihydrochloride | BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes | 4650 | |
| Lin28 1632 | Bromodomain inhibitor; promotes mESC differentiation; also RNA binding protein Lin28 inhibitor | 6068 | |
| DNA メチル化 | |||
| 5-Azacytidine | DNA methyltransferase inhibitor; enhances efficiency of somatic cell reprogramming | 3842 | |
| Decitabine | DNA methyltransferase inhibitor; demethylates differentiation related genes | 2624 | |
| RG 108 | Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of somatic cell reprogramming | 3295 | |
| Zebularine | DNA methyltransferase and cytidine deaminase inhibitor; potentiates differentiation of mesenchymal stem cells to cardiomyocytes | 2293 | |
| ヒストンアセチル化 | |||
| Anacardic acid | Histone acetyltransferase (HAT) inhibitor; promotes cardiomyocyte differentiation from mESCs | 3084 | |
| ヒストン脱アセチル化 | |||
| MC 1742 | Potent class I and IIb HDAC inhibitor | 5727 | |
| SAHA | Class I and II HDAC inhibitor; improves efficiency of reprogramming | 4652 | |
| Sodium butyrate | Histone deacetylase inhibitor; improves efficiency of reprogramming | 3850 | |
| Trichostatin A | Potent histone deacetylase inhibitor; improves efficiency of reprogramming | 1406 | |
| Valproic acid, sodium salt | Histone deacetylase inhibitor; improves efficiency of reprogramming | 2815 | |
| ヒストンメチル化 | |||
| 3-Deazaneplanocin A hydrochloride | EZH2 histone methyltransferase inhibitor; widely used in chemical reprogramming protocols | 4703 | |
| BIX 01294 | GLP and G9a inhibitor; potentiates induction of iPSCs | 3364 | |
| EPZ 004777 | Highly potent DOT1L inhibitor; improves reprogramming efficiency | 5567 | |
シグナル伝達
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| Hedgehog | |||
| Cyclopamine | Inhibitor of Hedgehog (Hh) signaling; induces differentiation of hESCs into hormone expressing endocrine cells | 1623 | |
| GANT 61 | GLI antagonist; inhibits Hedgehog (Hh) signaling | 3191 | |
| Hh-Ag1.5 | Potent and high affinity Smo receptor agonist; induces differentiation of PSCs into spinal motor and sensory neurons | 7807 | |
| 20(S)-Hydroxycholesterol | Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation | 4474 | |
| Integrins | |||
| BIO 5192 | Highly potent and selective inhibitor of integrin a4b1 (VLA-4); mobilizes HSCs and progenitors | 5051 | |
| BOP | Dual a9b1/a4b1 integrin inhibitor; preferentially mobilizes HSCs | 6047 | |
| TGFβ/BMP | |||
| Dorsomorphin dihydrochloride | BMP type I receptor inhibitor; also potent AMPK inhibitor promotes cardiomyocyte differentiation in mouse ESCs | 3093 | |
| SB 4 | Potent BMP4 agonist | 6881 | |
| Wnt/β-Catenin | |||
| BIO | Potent GSK-3b inhibitor; also inhibits cdks; maintains self-renewal and pluripotency of ESCs | 3194 | |
| endo-IWR 1 | Wnt/b-catenin signaling inhibitor; axin stabilizer; promotes endothelial cell specification of cardiac progenitors | 3532 | |
| IWP 2 | PORCN inhibitor; inhibits Wnt processing and secretion | 3533 | |
| QS 11 | ARFGAP1 inhibitor; modulates Wnt/b-catenin signaling | 3324 | |
| WIKI4 | Potent tankyrase inhibitor | 4855 | |
| その他 | |||
| 17-AAG | Selective Hsp90 inhibitor; protects neuroprogenitor cells against stress-induced apoptosis | 1515 | |
| Mitomycin C | DNA cross-linking antitumor agent; used for MEF/STO feeder layer preparation in stem cell culture | 3258 | |
| Pifithrin-a hydrobromide | p53 inhibitor; also aryl hydrocarbon receptor agonist; inhibits ESC self-renewal | 1267 | |
CRISPR
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| AZD 7762 hydrochloride | Enhances CRISPR-Cpf1-mediated genome editing; also potent and selective ATP-competitive Chk1 and Chk2 inhibitor | 5199 | |
| Brefeldin A | Enhances CRISPR-mediated HDR efficiency | 1231 | |
| (Z)-4-Hydroxytamoxifen | Activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing | 3412 | |
| KU 0060648 | Enhances HDR efficiency and attenuates NHEJ frequency | 4840 | |
| L-755,507 | Enhances CRISPR-mediated HDR efficiency | 2197 | |
| Nocodazole | Enhances HDR efficiency; also increases Cas9-mediated gene editing frequencies | 1228 | |
| NU 7441 | Enhances HDR efficiency and attenuates NHEJ frequency | 3712 | |
| SCR7 pyrazine | Enhances HDR efficiency | 5342 | |
その他
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| 幹細胞化合物-溶液タイプ | |||
| CHIR 99021 in solution | Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO | 8170 | |
| LDN 193189 in solution | Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water | 8150 | |
| Y-27632 in solution | Sterile-filtered 10 mM solution of Y-27632 pre-dissolved in water | 7000 | |
| 細胞外マトリックス | |||
| RGD peptide | Potent integrin inhibitor; can be incorporated into hyaluronic acid hydrogel for hMSCs delivery and increases hMSC spreading | 7723 | |
| ウイルス導入エンハンサー | |||
| Akti-1/2 | Enhances CAR and TCR retroviral transduction of human T cells; potent and selective dual Akt1 and 2 inhibitor | 5773 | |
| Cyclosporin A | Enhances lentiviral transduction; calcineurin inhibitor | 1101 | |
| Cyclosporin H | Enhances lentiviral transduction | 6982 | |
| Daunorubicin hydrochloride | Enhances adenoviral transduction; RNA synthesis inhibitor | 1467 | |
| 16,16-Dimethyl Prostaglandin E2 | Enhances lentiviral transduction; synthetic prostaglandin E2 (Cat. No. 2296) derivative | 4027 | |
| Etoposide | Enhances adenoviral transduction; topoisomerase II inhibitor | 1226 | |
| Polybrene | Enhances lentiviral and adenoviral transduction efficiency; also enhances DNA transfection in various cell types | 7711 | |
| Prostaglandin E2 | Enhances lentiviral transduction; endogenous prostanoid | 2296 | |
| Rapamycin | Enhances lentiviral transduction; mTOR inhibitor and immunosuppressant | 1292 | |
| SAHA | Enhances plasmid transduction; class I and II HDAC inhibitor | 4652 | |
| Staurosporine | Enhances lentiviral transduction; non-selective protein kinase inhibitor | 1285 | |
NSC 増殖・維持
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| A 83-01 | Increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of NSCs | 2939 | |
| CHIR 99021 | Selective GSK-3 inhibitor; enhances human somatic cell conversion to NSCs in combination with PD 0325901 (Catalog # 4192) | 4423 | |
| Compound E | Accelerates the induction of homogeneous, self-renewing NSCs from hPSC | 6476 | |
| LDN 193189 dihydrochloride | Promotes neural induction of hPSCs in combination with SB 431542 (Catalog # 1614) | 6053 | |
| ML 184 | Selective GPR55 agonist. Promotes NSC proliferation | 6668 | |
| N-Acetylcysteine | Glutathione (GSH) precursor; neural protective compound; prevents degeneration of oligodendrocyte progenitors and NSCs in vivo | 7874 | |
| P7C3 | Neuroprotective and proneurogenic compound; orally available | 4076 | |
| SB 203580 | Selective inhibitor of p38 MAPK; stimulates NSC proliferation and can be used to promote expansion of HSCs ex vivo | 1202 | |
| SB 431542 | Promotes neural induction of hPSCs in combination with LDN 193189 (Catalog # 6053) | 1614 | |
NSC 凍結保存
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| Chroman 1 | Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryopreservation | 7163 | |
| DMSO, Cell Cryopreserve Grade | Cryoprotective agent which penetrates the cell membrane. Protects the cells from dehydration and shrinking during freezing | 7726 | |
| Emricasan | Promotes survival of pluripotent stem cells in culture when used as part of the CEPT cocktail | 7310 | |
| Polyamine Supplement x1000 (lyophilized) | Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability | 7739 | |
| trans-ISRIB | Potent integrated stress response (ISR) inhibitor; improves survival of differentiated cells following cryopreservation when used as part of the CEPT cocktail | 5284 | |
| Y-27632 dihydrochloride | Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; increases survival of stem cells and differentiated cells undergoing cryopreservation and passaging | 1254 | |
NSC 分化
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| L-Ascorbic acid | Enhances the survival, growth and differentiation of hPSC derived neurons and astrocytes | 4055 | |
| CHIR 99021 | GSK-3 inhibitor; enhances differentiation of hPSCs into dopaminergic neurons | 4423 | |
| DAPT | γ-secretase inhibitor; induces terminal neuronal differentiation of neural progenitors | 2634 | |
| Forskolin | Adenylyl cyclase activator; induces terminal neuronal differentiation in NSCs; promotes hPSC differentiation into astrocytes | 1099 | |
| Hh-Ag1.5 | Induces differentiation of hPSCs spinal motor neurons and spinal sensory neurons | 7807 | |
| ISX 9 | Induces neuronal differentiation of SVZ progenitors | 4439 | |
| LDN 193189 dihydrochloride | ALK2 and ALK3 inhibitor; induces differentiation of hPSCs into nociceptive sensory neurons; promotes hPSC differentiation into astrocytes | 6053 | |
| LM 22A4 | BDNF mimetic; enhances the survival, growth and differentiation of neurons | 4607 | |
| PD 0332991 isethionate | Cyclin-dependent kinase 4/6 (CDK4/6) inhibitor; induces terminal neuronal differentiation of neural progenitors | 4786 | |
| Purmorphamine | Smo receptor agonist; induces differentiation of hPSCs into spinal motor neurons and GABAergic interneurons | 4551 | |
| Retinoic acid | Retinoic acid receptor agonist; promotes differentiation of hPSCs into neurons and glia | 0695 | |
| SAG | Smo receptor agonist; induces differentiation of hPSCs into dopaminergic neurons and GABAergic interneurons | 4366 | |
| T3 | Promotes differentiation of oligodendrocyte precursor cells in neonatal rats and in vitro | 6666 | |
| Valproic acid, sodium salt | Histone deacetylase inhibitor; promotes neuronal differentiation | 2815 | |
| XAV 939 | Tankyrase (TNKS) inhibitor; promotes cortical interneuron and striatal neuronal differentiation | 3748 | |
神経関連受容体・イオンチャネル
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| 2R,6R-Hydroxynorketamine hydrochloride | Enhances AMPA currents; decreases D-serine; lacks ketamine-related side effects | 6094 | |
| (+)-Bicuculline | Potent GABAA antagonist | 0130 | |
| C 101248 | Selective and potent inhibitor of both mouse and human THIK-1 | 8007 | |
| CGP 35348 | Brain penetrant, selective GABAB antagonist | 1245 | |
| CNQX disodium salt | Potent non-NMDA iGluR antagonist | 1045 | |
| D-GsMTx4 | TRPC1/6 and Piezo2 inhibitor | 7170 | |
| DL-AP5 | Potent, selective NMDA antagonist | 0105 | |
| GT 949 | Potent and selective positive allosteric modulator of EAAT2 | 6578 | |
| (+)-MK 801 maleate | Non-competitive NMDA antagonist, acts at ion channel site | 0924 | |
| MOG (35-55) | Myelin oligodendrocyte glycoprotein peptide; induces EAE in a mouse model of multiple sclerosis | 2568 | |
| MPEP hydrochloride | mGlu5 antagonist and positive allosteric modulator at mGlu4 | 1212 | |
| PE 22-28 | Potent inhibitor of TREK-1 channels | 7868 | |
| (S)-Norketamine hydrochloride | NMDA receptor modulator | 6112 | |
| Varenicline tartrate | Orally active, subtype-selective α4β2 partial agonist | 3754 | |
| VU 6005649 | Positive allosteric modulator of mGlu7 and mGlu8 receptors; NK1 antagonist | 6893 | |
| Xanomeline oxalate | Functionally selective M1 agonist | 3569 | |
ケージド化合物
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| ci-IP3/PM | Caged inositol triphosphate | 6210 | |
| CNV Dopamine | Caged dopamine; photolysed by UV light | 6354 | |
| DMNPE-4 AM-caged-calcium | Calcium cage; cell permeable | 5948 | |
| MNI-caged-L-glutamate | Stable photoreleaser of L-glutamate | 1490 | |
| RuBi GABA trimethylphosphine | Caged GABA; inhibits neural activity | 4709 | |
| RuBi-Glutamate | Caged glutamate; excited by visible wavelengths | 3574 | |
蛍光プローブ・染色
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| CELT-133 | Selective hα1A adrenergic receptor fluorescent antagonist | 7952 | |
| CELT-327 | Potent and selective hA2B/A3 adenosine receptor fluorescent antagonist | 7954 | |
| CELT-426 | Potent and partially selective hD2 dopamine receptor fluorescent antagonist | 7955 | |
| DAF FM diacetate | Cell permeable, photostable, nitric oxide fluorescent indicator | 7756 | |
| Di 4 ANEPPS | Voltage-sensitive probe; used to detect changes in membrane potential in electrophysiology protocols | 7324 | |
| FFN 206 dihydrochloride | Fluorescent VMAT2 substrate | 5043 | |
| Methoxy-X04 | Fluorescent amyloid β detector; brain penetrant | 4920 | |
| Mito-HE | Fluorescent mitochondrial superoxide indicator in live cells | 7641 | |
| MitoPY1 | Fluorescent mitochondrial hydrogen peroxide indicator | 4428 | |
| Sulforhodamine 101 | Red fluorescent dye; selective astrocyte marker | 5146 | |
| SynaptoRed C2 | Fluorescent dye; stains synaptic vesicles | 5118 | |
| Thioflavin T | Fluorescent amyloid stain, binds to the stacked β sheets of amyloid fibrils | 7122 | |
| Tocrifluor T1117 | Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Catalog # 1117) | 2540 | |
蛍光インジケーター
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| Fluo-4 AM | Cell-permeable, fluorescent Ca2+ indicator | 6255 | |
| FURA-2AM | Fluorescent Ca2+ indicator | 2220 | |
| Indo 1AM | Fluorescent Ca2+ indicator | 6704 | |
| Mag-Fura-2 AM | Magnesium (Mg2+) indicator, membrane permeable | 7855 | |
| MQAE | Fluorescent Cl- indicator; membrane permeable | 7856 | |
| OG 488 BAPTA-1 AM | Cell-permeable, fluorescent Ca2+ indicator | 6256 | |
| Phen Green SK diacetate | Heavy metal ion indicator, membrane permeable | 7873 | |
※掲載内容は 2026 年 3 月現在の情報に基づいています。