Tocris Bioscience 社 がん代謝を標的とした化合物
がん細胞は、正常細胞とは異なる代謝経路を活性化することで、急速な増殖と生存を可能にしています。がん代謝の主要なメカニズムに焦点を当て、研究に役立つ化合物を紹介しています。
Tocris Bioscience 社（以下 Tocris 社）が「がん代謝（Cancer Metabolism Research）」冊子を用意していますので、ぜひご覧ください。
※国内法規・特許により、一部弊社で取り扱いできない化合物がございます。
製品説明
がんに関連する代謝経路を標的とした約 150 種類の製品を紹介しています。
解糖系とグルコース代謝
- GAPDH
- Glycogen Synthase Kinase 3
- Lactate Dehydrogenase A
- NAMPT
- Phosphoglycerate Dehydrogenase
- Pyruvate Dehydrogenase
- Glucose Transporters
- Hexokinases
- Monocarboxylate Transporters
- PFKFB3
- PKM2
- SHMT
グルタミン代謝
- Ceramidases
- Glutaminase
- Glutamate Transporters
- L-type Amino Acid Transporter 1
クエン酸回路
- Glutamate Dehydrogenase
- Isocitrate Dehydrogenase 1
脂質合成
- Acetyl-CoA Carboxylase
- Farnesyl Diphosphate (FPP) Synthase
- Fatty Acid Desaturase 2
- HMG-CoA Reductase
- ATP Citrate Lyase
- Fatty Acid Amide Hydrolase
- Fatty Acid Synthase
- MAGL
一炭素代謝および核酸合成
- Dihydrofolate Reductase
- FTO
- IMPDH
- MutT Homolog-1
- Thymidylate Synthetase
- Dihydroorotate Dehydrogenase
- G6PD
- MTHFD2
- Ribonucleotide Reductase
関連資料
Tocris 社では、がん研究をサポートするため、特定分野の冊子を用意しています！
価格表
各製品の容量は、オンラインカタログでご確認いただけます。
代謝経路
| カテゴリー | 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|---|
| Autophagy | ||||
| Autophagy | Hydroxychloroquine | Autophagy inhibitor; also TLR9 inhibitor | 5648 |  |
| SMER 28 | Positive regulator of autophagy | 4297 | |
|
| Glucose Metabolism/ Glycolysis | ||||
| GAPDH | CGP 3466B | GAPDH inhibitor; neuroprotective | 2966 | |
| Glucose Transporters | BAY 876 | Potent and selective GLUT1 inhibitor | 6199 | |
| Fasentin | GLUT1/GLUT4 inhibitor; also Fas-sensitizer | 6100 | |
|
| WZB 117 | GLUT inhibitor | 6143 | |
|
| Glycogen Synthase Kinase 3 | CHIR 98014 | Highly potent and selective GSK-3 inhibitor | 6695 | |
| CHIR 99021 | Highly selective GSK-3 inhibitor; acts as Wnt activator | 4423 | |
|
| SB 216763 | Potent, selective GSK-3 inhibitor | 1616 | |
|
| Hexokinases | GKA 50 | Glucokinase activator | 5133 | |
| Lactate Dehydrogenase A | Galloflavin | Lactate dehydrogenase inhibitor; impairs aerobic glycolysis | 4795 | |
| GSK 2837808A | Potent and selective LDHA inhibitor | 5189 | |
|
| NHI 2 | LDHA inhibitor | 5363 | |
|
| Monocarboxylate Transporters | 3-Bromopyruvate | MCT1 inhibitor; also inhibits hexokinase II | 7512 | |
| AR-C 141990 | MCT1 inhibitor | 5658 | |
|
| AR-C155858 | MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells | 4960 | |
|
| SR 13800 | Potent MCT1 inhibitor | 5431 | |
|
| UK 5099 | MCT inhibitor; also inhibits pyruvate transport | 4186 | |
|
| NAMPT | CHS 828 | NAMPT inhibitor; active in vivo and cytotoxic | 6753 | |
| NAMPT PROTAC® A7 | Potent and selective NAMPT Degrader; reduces NAMPT levels in tumor cells | 7842 | |
|
| P7C3 | NAMPT activator; also proneurogenic and neuroprotective | 4076 | |
|
| STF 31 | NAMPT inhibitor; also GLUT1 inhibitor | 4484 | |
|
| PFKFB3 | 3PO | PFKFB3 inhibitor | 5121 | |
| AZ PFKFB3 26 | Potent and selective PFKFB3 inhibitor | 5675 | |
|
| AZ PFKFB3 67 | Potent and selective PFKFB3 inhibitor | 5742 | |
|
| PFK 15 | Selective PFKFB3 inhibitor | 5339 | |
|
| Phosphoglycerate Dehydrogenase | PKUMDL WQ 2101 | Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH) | 6580 | |
| PKUMDL WQ 2201 | Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH) | 6581 | |
|
| Pyruvate Dehydrogenase | 6,8-Bis(benzylthio) octanoic acid | PDH and KGDH inhibitor | 5348 | |
| Ranolazine | Activates pyruvate dehydrogenase; antianginal | 3118 | |
|
| Pyruvate Dehydrogenase Kinase | DCA | Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor | 2755 | |
| SHMT | SHIN1 | Potent serine hydroxymethyltransferase (SHMT) inhibitor | 6998 | |
| Glutamine Metabolism | ||||
| Ceramidases | Ceranib 1 | Ceramidase inhibitor; antiproliferative | 4448 | |
| Glutamate Transporters | Dihydrokainic acid | EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake | 0111 | |
| DL-TBOA | Selective non-transportable inhibitor of EAATs | 1223 | |
|
| GT 949 | Potent and selective positive allosteric modulator of EAAT2 | 6578 | |
|
| TFB-TBOA | High affinity EAAT1 and EAAT2 blocker | 2532 | |
|
| UCPH 101 | Selective non-substrate EAAT1 inhibitor | 3490 | |
|
| WAY 213613 | Potent, non-substrate EAAT2 inhibitor | 2652 | |
|
| Glutaminase | 968 | Allosteric inhibitor of glutaminase | 5460 | |
| BPTES | Selective allosteric glutaminase (GLS1) inhibitor | 5301 | |
|
| L-type Amino Acid Transporter 1 | JPH 203（KYT 0353） | Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | 5026 | |
| Lipid Metabolism | ||||
| Acetyl-CoA Carboxylase | PF 05175157 | Acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor | 5790 | |
| ATP Citrate Lyase | BMS 303141 | ATP citrate lyase inhibitor; orally bioavailable | 4609 | |
| SB 204990 | ATP citrate lyase (ACLY) inhibitor | 4962 | |
|
| Farnesyl Diphosphate (FPP) Synthase | Zoledronic Acid | Potent farnesyl diphosphate (FPP) synthase inhibitor | 6111 | |
| Fatty Acid Amide Hydrolase | JZL 195 | Dual FAAH and MAGL inhibitor | 4715 | |
| PF 3845 | Selective FAAH inhibitor | 4175 | |
|
| TC-F 2 | Potent, reversible and selective FAAH inhibitor | 4355 | |
|
| URB 597 | Potent and selective FAAH inhibitor | 4612 | |
|
| Fatty Acid Desaturase 2 | SC 26196 | Selective fatty acid desaturase 2 inhibitor | 4189 | |
| T 3364366 | Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable | 6106 | |
|
| Fatty Acid Synthase | C 75 | Potent fatty acid synthase inhibitor; proapoptotic | 2489 | |
| GSK 2194069 | Potent human fatty acid synthase (hFASN) inhibitor | 5303 | |
|
| Orlistat | Inhibits the thioesterase domain of fatty acid synthase; also carboxylester lipase inhibitor | 3540 | |
|
| HMG-CoA Reductase | Fluvastatin sodium | Potent HMG-CoA reductase inhibitor | 3309 | |
| Lovastatin | Potent HMG-CoA reductase inhibitor | 1530 | |
|
| Rosuvastatin calcium | Potent HMG-CoA reductase inhibitor | 6343 | |
|
| Simvastatin | HMG-CoA reductase inhibitor | 1965 | |
|
| SR 12813 | Pregnane X receptor agonist; promotes degradation of HMG-CoA reductase | 2969 | |
|
| MAGL | JZL 184 | Potent MAGL inhibitor | 3836 | |
| JZP 361 | Potent and selective reversible MAGL inhibitor | 5851 | |
|
| Other Lipid Metabolism | LDN 193188 | Inhibitor of phosphatidylcholine transfer protein (PC-TP) | 5631 | |
| Lomitapide | Potent microsomal triglyceride transfer protein (MTP) inhibitor | 7492 | |
|
| Ro 48-8071 | 2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis | 5389 | |
|
| Triacsin C | Inhibitor of acyl-CoA synthetase | 2472 | |
|
| Mitochondria | ||||
| ATP Synthase | Bz 423 | ATP synthase inhibitor; proapoptotic | 5791 | |
| Hexokinases | Lonidamine | Mitochondrial hexokinase inhibitor | 1646 | |
| Malate Dehydrogenase | LW 6 | Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α | 6322 | |
| Mitochondria Complex 1 | Metformin | Mitochondrial complex I inhibitor; also activator of LKB1/AMPK; antidiabetic agent | 2864 | |
| Mitochondrial ATPase | Oligomycin A | Inhibitor of mitochondrial ATPase | 4110 | |
| Monoamine Oxidase | Lazabemide | Selective MAO-B inhibitor | 2460 | |
| Moclobemide | Reversible MAO-A inhibitor | 4395 | |
|
| Nucleotides | ||||
| Dihydrofolate Reductase | Phototrexate | Photoswitchable inhibitor of human dihydrofolate reductase | 7362 | |
| Pyrimethamine | DHFR inhibitor; also inhibits STAT3 and multidrug and toxin extrusion (MATE) transporters | 3918 | |
|
| Dihydroorotate Dehydrogenase | Brequinar sodium | Potent and selective DHODH inhibitor | 6196 | |
| Teriflunomide | Inhibitor of DHODH; active metabolite of Leflunomide | 5069 | |
|
| FTO | Ethyl LipotF | Selective FTO inhibitor | 5950 | |
| MO-I-500 | FTO inhibitor; anticonvulsant | 6871 | |
|
| G6PD | G6PDi | Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor | 7561 | |
| Inosine Monophosphatase Dehydrogenase | BMS 566419 | Inosine monophosphatase dehydrogenase (IMPDH) inhibitor | 5492 | |
| Mycophenolic acid | Inosine monophosphatase dehydrogenase (IMPDH) inhibitor | 1505 | |
|
| MTHFD2 | TH 9619 | Potent inhibitor of methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2); inhibits purine synthesis from serine | 7719 | |
| MutT Homolog-1 | (S)-Crizotinib | MTH1 inhibitor | 6025 | |
| BAY 707 | Potent and selective MTH1 inhibitor | 6562 | |
|
| Other Oxygenases/ Oxidases | Bobcat339 | Ten-eleven translocation methylcytosine dioxygenase (TET) inhibitor | 6977 | |
| Febuxostat | Xanthine oxidase inhibitor | 4427 | |
|
| Ribonucleotide Reductase | 3-AP | Ribonucleotide reductase inhibitor; also an iron chelator | 5962 | |
| Cladribine | Deoxyadenosine analog; pro-apoptotic | 5292 | |
|
| Thymidylate Synthetase | 5-Fluorouracil | Thymidylate synthetase inhibitor | 3257 | |
| Methotrexate | Thymidylate synthetase inhibitor also inhibits dihydrofolate reductase | 1230 | |
|
| Pemetrexed | Thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART | 6185 | |
|
| Oxphos | ||||
| Oxidative Phosphorylation | BAM 15 | Mitochondrial protonophore uncoupler | 5737 | |
| CCCP | Oxidative phosphorylation uncoupler | 0452 | |
|
| FCCP | Oxidative phosphorylation uncoupler | 0453 | |
|
| Rotenone | Inhibits complex I of the mitochondrial electron transport chain | 3616 | |
|
| TCA Cycle | ||||
| Glutamate Dehydrogenase | EGCG | GDH inhibitor; also β-secretase and DNMT1 inhibitor | 4524 | |
| Isocitrate Dehydrogenase 1 | AGI 5198 | Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1) | 7087 | |
| Other Dehydrogenases | 6,8-Bis(benzylthio) octanoic acid | PDH and KGDH inhibitor | 5348 | |
| (RS)-2-Hydroxyglutaric acid | Oncometabolite; synthesized by mIDH1 | 6122 | |
|
| Methylmalonate | Succinate dehydrogenase inhibitor | 4979 | |
|
| Other Metabolism | ||||
| Aldehyde Dehydrogenase | A37 | ALDH1A1 inhibitor | 5802 | |
| NCT 501 | Potent and selective ALDH1A1 inhibitor | 5934 | |
|
| WIN 18446 | ALDH1A2 inhibitor | 4736 | |
|
| Carbonic Anhydrases | STX 64 | Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II | 7341 | |
| DNA, RNA and Protein Synthesis |
Gemcitabine | DNA synthesis inhibitor | 3259 | |
| Homoharringtonine | Inhibitor of protein synthesis; antileukemic agent | 1416 | |
|
| Hypoxia Inducible Factors | Echinomycin | Highly potent and selective HIF-1α inhibitor | 5520 | |
| VH 298 | High-affinity inhibitor of E3 ubiquitin ligase VHL; blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation | 6156 | |
|
| Na+/H+ Exchanger | BIX NHE1 inhibitor | Potent and selective NHE1 inhibitor | 5512 | |
| Cariporide | Selective NHE1 inhibitor; cardioprotective and antitumor | 5358 | |
|
| EIPA | Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE) | 3378 | |
|
| Zoniporide | Selective NHE1 inhibitor | 2727 | |
|
| NADPH Oxidase | Apocynin | NADPH-oxidase inhibitor | 4663 | |
| GSK 2795039 | NADPH oxidase 2 (NOX2) inhibitor | 6848 | |
|
| VAS 2870 | NADPH oxidase (Nox) inhibitor | 6654 | |
|
| Nrf2 | CDDO Im | Nrf2 signaling activator; induces expression of genes encoding antioxidant proteins | 4737 | |
| ML 385 | Nrf2 inhibitor; blocks expression of Nrf2 downstream targets | 6243 | |
|
| Other Dehydrogenases | SW 033291 | High affinity 15-hydroxyprostaglandin dehydrogenase (15 PGDH) inhibitor; promotes hematopoiesis and hepatocyte proliferation | 5759 | |
| Other Oxygenases/ Oxidases | Nitazoxanide | Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective | 7234 | |
| PF 06281355 | Selective myeloperoxidase (MPO) inhibitor | 6004 | |
|
| Other Synthases/ Synthetases | Halofuginone | High affinity competitive prolyl-tRNA synthetase inhibitor | 1993 | |
| HQL 79 | Human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor | 3530 | |
|
| TFC 007 | Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor | 5108 | |
|
駆動因子
| カテゴリー | 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|---|
| Akt (Protein Kinase B) | 10-DEBC | Selective inhibitor of Akt/PKB; suppresses downstream activation of mTOR | 2558 | |
| Akti-1/2 | Potent and selective dual Akt1 and 2 inhibitor | 5773 | |
|
| LY 294002 | Prototypical PI 3-kinase inhibitor; also inhibits other kinases | 1130 | |
|
| MK 2206 | Potent and selective allosteric Akt inhibitor | 7850 | |
|
| SC 79 | Akt activator | 4635 | |
|
| mTOR | PP 242 | Dual mTORC1/mTORC2 inhibitor | 4257 | |
| Rapamycin | mTOR inhibitor | 1292 | |
|
| Torin 1 | Potent and selective ATP-competitive mTOR inhibitor | 4247 | |
|
| Torin 2 | Potent and selective mTOR inhibitor | 4248 | |
|
| Myc | 10058-F4 | Cell permeable inhibitor of c-Myc-Max dimerization; decreases glucose uptake and expression of glycolysis-associated genes | 4406 | |
| KJ Pyr 9 | High affinity Myc inhibitor; disrupts Myc-Max interaction | 5306 | |
|
| Sodium Butyrate | Downregulates expression of c-Myc; histone deacetylase inhibitor | 3850 | |
|
| Ras GTPases | GGTI 298 | Geranylgeranyltransferase I (GGTase I) inhibitor | 2430 | |
| LC 2 | Selective KRAS PROTAC® Degrader; induces selective degradation of KRASG12C; negative control (Cat. No. 7421) also available | 7420 | |
|
| Lonafarnib | Potent farnesyltransferase inhibitor | 6265 | |
検出
| 製品名 | 作用 | メーカー 製品番号 |
オンライン カタログへ |
|---|---|---|---|
| 2-NBDG | Glucose uptake probe | 6065 | |
| L 012 Sodium Salt | ROS and RNS indicator | 5085 | |
| Mito-HE | Mitochondrial superoxide indicator | 7641 | |
| MitoBrilliant 646 | Fluorescent mitochondrial stain; suitable for use in both live and fixed cells | 7700 | |
| MitoPY1 | Mitochondrial hydrogen peroxide indicator | 4428 | |
| Pimonidazole | Hypoxia detection agent | 6182 | |
※掲載内容は 2025 年 9 月現在の情報に基づいています。