Tocris Bioscience社 Targeting RNA with Small Molecules
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Non-coding RNAs, such as ribosomal RNAs and micro RNAs, fold into complex 3D structures, which are involved in key cellular processes such as protein translation, RNA splicing, DNA replication and regulation of gene expression. These diverse and central roles make RNA an attractive target for innovative drug discovery. In order to develop small molecules for RNA targets, structural information on the fold and flexibility of the RNA strand must be determined. Learn more about RNA as a drug target in this paper in J. Med. Chem; How we think about targeting RNA with small molecules. Costales et al (2020).
Featured Product Inhibits Formation of miR-210
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Reagents for RNA SHAPE-MaP Chemistry Selective 2'- Hydroxyl (2'-OH) Acylation and Primer Extension (SHAPE) and SHAPE-MaP reagents are used for the determination of complex, secondary RNA structures formed by RNA forming base pairs with itself and its interaction with other molecules. Compounds such as NAI and 1M7 below, are rapidly absorbed into cells and react with RNA based on differences in 2'-OH reactivity of single- and double-stranded RNA. Reactivity differences allow researchers to distinguish between flexible and folded regions of RNA, enabling a deeper understanding of structural interactions that can be exploited for drug development. |
NAI (Cat. No. 7004)
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1M7 (Cat. No. 6602)
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Learn more about SHAPE and SHAPE-MaP in this detailed review and protocol outline from Smola & Weeks, (2018) In-cell RNA structure probing with SHAPE-MaP. Nature Protocols. |
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