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Recent advances in neuroscience have provided researchers with new state of the art tools to investigate the complex neural networks underlying behaviors in health and disease. These include:

• Chemogenetic tools for control of neuronal activity
• Caged compounds that release ligands when stimulated with light
• False Fluorescent Neurotransmitters (FFNs) for imaging synaptic vesicles
• Fluorescent calcium signaling probes for electrophysiology

Chemogenetic Tools

We have recently expanded our range of chemogenetic tools. As well as DREADD ligands, our range now includes ultrapotent PSEMs (uPSEMs) for the modulation of neuronal activity in vivo, via chimeric ion channels known as PSAMs.

Deschloroclozapine (DCZ)

Deschloroclozapine is a highly potent and selective hM 3D q and hM 4D i DREADD agonist, which displays superior specificity and blood brain barrier penetration making it an excellent
option for in vivo electrophysiology experiments.

uPSEM 817

Selective ultrapotent agonist for PSAM ⁴-GlyR and PSAM ⁴-5-HT ₃ chimeric ion channels. Suppresses firing of layer 2/3 cortical neurons expressing PSAM ⁴-GlyR in brain slices. Brain penetrant in vivo.

Featured Caged Compounds

Caged compounds enable the precise timed release of ligands adjacent to their receptors, reducing the effects of diffusion on the size and kinetics of the receptor’s response to the ligand. This is particularly useful in complex tissues preparations such as brain slices.

False Fluorescent Neurotransmitters (FFNs)

FFNs are fluorescent substrates for neurotransmitter transporters, which allow imaging of synaptic vesicles within the nerve terminal and synaptic cleft.

• FFN 102 - DAT and VMAT2 substrate
• FFN 200 - VMAT2 substrate
• FFN 270 - NET and VMAT2 substrate