ACROBiosystems社 Extra caution for safety and efficacy evaluation of COVID-19 vaccines
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| According to the landscape documents of COVID-19 candidate vaccines prepared by the World Health Organization, there are 44 candidate vaccines in clinical trials globally, 10 of which are in Phase III (Table 1). Additionally, we have 154 candidate vaccines in the preclinical stage worldwide. | ||||
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Table 1. Ten candidate vaccines in Phase III clinical trial
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Due to the rush of vaccine development and the insufficient understanding of the vaccine's immune responses, extra caution could be used when evaluating the safety and efficacy of the vaccine. Two major studies of the COVID-19 vaccine from AstraZeneca and Johnson& Johnson, both paused because of potential safety concerns earlier. However, announced last Friday, both trials are set to restart.
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ACROBiosystems has developed a series of critical reagents for COVID-19 vaccine development and evaluation, including trimeric S protein which performed a high ratio of signal to noise (S/N), antibodies for reference and ELISA kits which are under progress of CE certification and can make your experiment easier. These featured products are suitable for IgG/M antibody titer detection, neutralizing antibody titer detection and antigen titer detection to accelerate the vaccine development.
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>>> Application 1: Vaccine immunogenicity evaluation ----- IgG antibody measurement >> Recommended products |
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Cat. No. SPN-C52H9
Product:
SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS & NS-EM verified)
Application:
Can be used in IgG antibody titer assay by ELISA method.
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Cat. No. TAS-K007
Product:
Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein trimer)
Application:
A rapid and effective assay kit for IgG antibody quantification in serum/plasma samples.
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Cat. No. TAS-K002 Product:
Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein RBD)
Application:
A rapid and effective assay kit for IgG antibody quantification in serum/plasma samples.
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>>> Application 2: Vaccine clinical immunogenicity evaluation ----- Neutralizing antibody measurement >> Recommended products |
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Cat. No. TAS-K003
Product:
Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay kit
Application:
This kit is intended for serologic measurement for the titer of Anti-SARS-CoV-2 neutralizing antibody in serum/plasma samples.
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Cat. No. SPD-M128
Product:
Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128)
Application:
This neutralizing antibody was verified using a pseudotyped virus. It is designed as a standard reference for the vaccine evaluation assays.
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>>> Application 3: Vaccine post-market evaluation ----- Neutralizing antibody measurement (Diagnostic kit development） >> Recommended products |
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Cat. No. SPD-C52H1
Product:
SARS-CoV-2 (COVID-19) S protein RBD, His Tag
Application: Lateral Flow Assay |
Cat. No. AC2-H52H8
Product:
Human ACE2 /ACEH Protein, His Tag (MALS verified)
Application: Lateral Flow Assay |
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Additionally, ACROBiosystems developed a series of useful products, which can be used for anti-SARS-CoV-2 IgG1, IgG2, IgG3 and IgG4 detection.
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>>> More critical reagents for vaccine development and evaluation
>>> More antigens & antibodies for diagnostic kit development
Read about how ACROBiosystems has been involved in the fight against COVID-19:
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References |
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