ACROBiosystems社 ACRO Weekly - The latest news for you
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Inspiring Protein Targets G Protein-coupled Receptors (GPCRs)
G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and have also been implicated in a large number of diseases, such as type 2 diabetes mellitus (T2DM), obesity, depression, cancer, and many others. Therefore, GPCRs have become the most successful drug targets for the treatment of a variety of diseases.
ACROBiosystems has launched several full-length transmembrane proteins including PAR2, CXCR6, GPRC5B, and CXCR3 based on a multi-pass transmembrane proteins development technology platform to accelerate GPCRs targeted drug development!
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Establishing a more accurate neurodegenerative disease model
A hallmark of neurodegenerative diseases is the aggregation of certain proteins in patient brains due to misfolding, deposition, and entanglement that leads to neurodegeneration. Due to the varying mechanisms that lead to protein aggregation, building a reliable and accurate disease model to understand pathogenesis is challenging. Induced PFFs are designed to mimic naturally occurring pathological states and processes.
To help provide you with better tools for neurodegenerative disease modeling, we offer both Tau-441 and α-syn PFFs that closely resemble filaments found in vivo.
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Read our insight article on Pre-formed Fibrils!
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Inspiring Protein Targets Trophoblast Antigen 2 (TROP-2)
With the expansion of the TROP-2 targeting pipeline, companion diagnostics are critical in evaluating the best therapy for patients. This includes immunohistochemistry (IHC), which is the classical method for predicting tumor response to target-specific therapies. Explore our IHC antibodies, including TROP-2 below!
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References 1Spillantini M., Crowther R., et al. Proc. Natl. Acad. Sci. Vol. 95, pp. 6469 – 6473. |
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