ACROBiosystems社 Cathepsin B For AGLink® ADC Site-specific conjugation kit
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Cathepsin B For AGLink® ADC Site-specific conjugation kit
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Various factors during development can affect the efficacy of antibody-drug conjugates (ADCs), among which conjugation technology is a very important factor. A site-specific conjugation method precisely controls the conjugation site, producing a homogenous mixture, which is an especially promising path to improving ADC design. ACROBiosystems utilize AGLink® site-specific conjugation kit to perform site-specific enzymatic modification of IgG Fc glycans and evaluate ADC conjugation homogeneity and cytotoxicity.
Features
>> Site-specific conjugation through Fc-glycans with high conjugation efficiency.
>> Uniform DAR value that result in a highly homogeneous ADC products.
>> Universal and efficient: Eliminate amino acid sequence evaluations.
>> Easy to use: One-pot conjugation method.
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Product List
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Cat. No.
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Product Description
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Size
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ADC-P001
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AGlink ADC Conjugation Kit (MMAE, DAR4)
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1 Reaction, 2mg antibody conjugation
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ADC-P002
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AGlink ADC Conjugation Kit (MMAE, DAR2)
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1 Reaction, 2mg antibody conjugation
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Verification data
The Linker contained in the kit can be cleavaged by Cathepsin B，ACROBiosystems can provide high quality Cathepsin B proteases to Evaluate the effect of proteases cleavage of linker to ensure the efficient release of the intracellular payloads.
Features
>> Natural conformation: HEK293 expressed protein to ensure the natural structure;
>> High enzyme activity: enzyme activity > 2,500 pmol/min/µg.
More proteases for peptide linker
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