AcroBiosystems社 Combination of CTLA-4 and PD-1 blockers for the treatment of cancer
Combination of CTLA-4 and PD-1 blockers for the treatment of cancer
Immune checkpoint regulators, such as programmed cell death protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on T cells, help to enhance the body's own immune anticancer response. Targeting checkpoints of immune cell activation has been demonstrated to be the most effective approach for the activation of anti-tumor immune responses. CTLA-4 and PD-1, both inhibitory checkpoints that are commonly seen on activated T-cells have been found to be the most reliable targets for the treatment of cancer.
However, the effect is not good when administered as monotherapy. Efficacy of the combination has been shown in several published studies and is under evaluation in multiple ongoing studies. A combination of CTLA-4 and PD-1 blockers was suggested to have a synergistic effect on activation of anti-tumor immune response and to increase the response rates in patients.
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High bioactivity verified by ELISA
Quantitative Analysis of CTLA-4 x OX40 Bispecific Antibody in Human Serum by Intact Assay. Immobilized Human OX40 Protein, His Tag (MALS verified) (Cat. No. OX0-H5224) at 2 μg/mL, add increasing concentrations of CTLA-4 x OX40 bispecific antibody in 50% Human serum and then add Biotinylated Human CTLA-4, His, Avitag (Cat. No. CT4-H82E3) at 0.2 μg/mL. Detection was performed using HRP-conjugated streptavidin with a sensitivity of 4 ng/mL (Intact assay, routinely tested).
High bioactivity verified by SPR
Biotinylated Human CTLA-4, His, Avitag (Cat. No. CT4-H82E3) captured on Biotin CAP - Series S sensor Chip can bind Yervoy (Ipilimumab) with an affinity constant of 0.635 nM as determined in an SPR assay (Biacore T200) (Routinely tested).
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