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ACROBiosystems社 Comprehensive Fc Receptor Proteins Support Antibody Drug Development

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Comprehensive Fc Receptor Proteins Support Antibody Drug Development

Fc Receptor, a class of cell surface proteins that binds specifically to the Fc fragments of antibodies and induce immune responses, plays an important role in antibody drug modification. ADCC is one of the important mechanisms by which antibody drugs kill tumor cells or pathogenic microorganisms, and NK cells, macrophages and neutrophils are known to be involved in ADCC action. And studies have shown that the high affinity of Fc tail and FcγRIIIA is beneficial to the efficacy of antibody drugs.

ACROBiosystems offers a comprehensive collection of recombinant Fc receptor proteins, including their common variants, to expedite your antibody drug development.

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Fc Receptor Proteins-Affinity Verified by Antibody Binding

ACRO_3.jpgHuman CD64, His Tag (Cat. No. FCA-H52H1) captured on CM5 chip via anti-His antibody can bind Herceptin® with an affinity constant of 4.92 nM as determined in a SPR assay (Biacore 8K) (QC tested).

ACRO_4.jpgLoaded Human CD64, His Tag (Cat. No. FCA-H52H1) on HIS1K Biosensor, can bind Herceptin with an affinity constant of 6.98 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

High Batch-to-batch Consistency

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Immobilized Human Fc gamma RIIB / CD32b Protein (Cat. No. CDB-H5228) on CM5 Chip via anti-His antibody, can bind Ritux*mab with an affinity constant of 10 μM as determined in a SPR assay (Biacore T200).

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