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Facilitating DC vaccine development

Dendritic cells (DCs) are the most potent antigen-presenting cells known in the human body that activate T cells. Their unique physiological advantages have led to the development of DC vaccines, which are popular in cancer treatment. Currently, several DC vaccines have been approved globally for indications such as renal cancer, liver cancer, and prostate cancer.

Protocols for generation of tolerogenic and immunogenic dendritic cells from monocytic precursors. Frontiers in immunology, 4, 82.

ACROBiosystems is now releasing a new series of GMP-grade growth factors specifically designed for DC cell differentiation and cultivation including GM-CSF, IL-4, TNF-α, IFN-γ, IL-6, IL-1b, and FLT-3 ligand. These factors boast high activity, safety, and lot-to-lot consistency while better supporting the large-scale clinical production of DC vaccines (cell therapy).

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