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AcroBiosystems社 Leukocyte Immunoglobulin-Like Receptors a new window of opportunity to immune therapy

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Leukocyte Immunoglobulin-Like Receptors: a new window of opportunity to immune therapy

The leukocyte immunoglobulin-like receptors (LILRs), are a family of immunoregulatory receptors expressed by a range of hematopoietic cell types. While the LILRA receptors promote immune cell activation by signaling through immunoreceptor tyrosine-based activation motifs (ITAMs), the LILRB receptors inhibit immune cell activation by signaling through immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

Showing potential in some monoclonal/bispecific antibodies, ADCs, and cell therapy related drugs,LILRBs especially LILRB2 and LILRB4,  represent attractive targets for cancer treatment. 

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Click at the molecule name to find out the clinical and translational updates:

LILRB1

LILRB2

LILRB3

LILRB4

LILRB5

LILRA1

LILRA2

LILRA3

LILRA5

LILRA6

ACROBiosystems has successfully developed a series of high-quality LILRs proteins that can be used in immunization, antibody screening, and cross-species experiments, etc.

 

>> Comprehensive products: Almost all covered molecules of the LILRs family;

>> Multiple species: Human, Mouse, Cynomolgus species, can be fully applied to different cross specie experiments;

>> High purity: SEC-MALS verification purity>90%;

>> High bioactivity verified by ELISA & SPR, and the affinity verified by antibody and ligand binding.

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