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AcroBiosystems社 Neutralization of N501Y mutant SARS-CoV-2

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Neutralization_of_N501Y_mutant_SARS-CoV-2_by_BNT162b2_vaccine-elicited_sera_1.png
Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera
Neutralization_of_N501Y_mutant_SARS-CoV-2_by_BNT162b2_vaccine-elicited_sera_2.png

Rapidly spreading variants of SARS-CoV-2 that have arisen in the United Kingdom and South Africa share the spike N501Y substitution, which is of particular concern because it is located in the viral receptor binding site for cell entry and increases binding to the receptor. 

The results from an in vitro study conducted by the University of Texas Medical Branch (UTMB) and Pfizer shows the antibodies from people who have received the Comirnaty COVID-19 vaccine effectively neutralize SARS-CoV-2 with a key mutation that is also found in two highly transmissible strains.

List of SARS-CoV-2 Spike Mutants

N501Y

HV69-70del

D614G

P681H

Y144del

T716I

A570D

S982A

D1118H

Cat.No.

Product   description

Preorder

SPD-C52Hn SARS-CoV-2 (COVID-19) S protein RBD (N501Y), His Tag ​​​​​​Preorder
SPD-C52Hp SARS-CoV-2 (COVID-19) S protein RBD (K417N, E484K, N501Y), His Tag Preorder
S1N-C52Hd SARS-CoV-2 (COVID-19) S1 protein (HV69-70del), His Tag Preorder
S1N-C52Hg SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag Preorder
S1N-C5256 SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag Preorder
S1N-C52Hk SARS-CoV-2 (COVID-19) S1 protein (HV69-70del, N501Y, D614G), His Tag Preorder
SPN-C52H6 SARS-CoV-2 (COVID-19) S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag Preorder

>>> Click to find out more SARS-CoV-2 protein mutants

 

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The Process of How SARS-CoV-2 Infects the Host

Neutralization_of_N501Y_mutant_SARS-CoV-2_by_BNT162b2_vaccine-elicited_sera_3.png

Related Article:

Positive Phase 1/2 Study Results of Pfizer COVID-19 mRNA Vaccine

Reference:

http://life.acrobiosystems.cn/e/535472/nt-10-1101-2021-01-07-425740v1/2r4zl3m/1084311372?h=B1WQhSdbeKMlNh2XQ7MMQH53YfXDeqmAOySGRwq29AY

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