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ACROBiosystems社 Pfizer & BioNTech published positive Phase 1/2 interim report of mRNA vaccine

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Pfizer & BioNTech published positive Phase 1/2 interim report of mRNA vaccine

 

Phase 1/2 interim report of Pfizer’s mRNA vaccine encoding trimerized SARS-CoV-2 spike glycoprotein RBD was published on medRxiv preprint recently. ACROBiosystems proudly supplies all functional COVID-19 antigens for IgG assay.

In the RBD-binding IgG assay, the biotinylated S protein RBD from ACROBiosystems Cat.No. SPD-C82E9）was bound to streptavidin-coated Luminex microspheres.

By employing the unique Avitag™ technology, ACROBiosystems developed a series of SARS-CoV-2 related biotinylated recombinant proteins which are in high purity and activity and perform good affinity. These biotinylated proteins are suitable in different applications of SARS-CoV-2 related drugs, vaccines and diagnostic test development.

 

Product List

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Biotinylated Spike protein trimer and HEK 293 cells expressed Nucleocapsid protein are coming soon!

 

Assay data

※ SDS-PAGE & SEC-MALS-High purity & homogeneity

Fig_1_The_purity_of_Biotinylated_SARS-CoV-2_S_protein_RBD_His_Avitag_Cat_No_SPD-C82E9.pngFig 1 The purity of Biotinylated SARS-CoV-2 S protein RBD, His,Avitag (Cat. No. SPD-C82E9) is greater than 90% verified by SDS-PAGE and SEC-MALS.

 

※ELISA-High bioactivity

Fig_2_Immobilized Human_ACE2_Fc_Tag_Cat_No_AC2-H5257.jpgFig 2 Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5257) at 2 μg/mL (100 μL/well) can bind Biotinylated SARS-CoV-2 S protein RBD, His,Avitag (Cat. No. SPD-C82E9) with a linear range of 4-125 ng/mL.

※>>> Protocol

 

※BLI-High affinity

Fig_3_Loaded_Biotinylated_SARS-CoV-2_S_protein_RBD_His_Avitag_Cat_No_SPD-C82E9.jpgFig 3 Loaded Biotinylated SARS-CoV-2 S protein RBD, His,Avitag (Cat. No. SPD-C82E9) on SA Biosensor, can bind Human ACE2, His Tag (Cat. No. AC2-H52H8) with an affinity constant of 5.86 nM as determined in BLI assay (ForteBio Octet Red96e).

※>>> Protocol

Additionally, ACROBiosystems has also developed a series of antibody titer assay kits to accelerate the drug and vaccine research and development.

Product list

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Reference:


Mulligan et al., (2020). Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. medRxiv, doi: http://life.acrobiosystems.cn/e/535472/10-1101-2020-06-30-20142570/2h38mcz/955917697?h=tMzz_uWBP72av7fV10jFkFsaibm5M-Ka9j5Z0bLJvpw

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