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AcroBiosystems社 Treatment of Cancer Improved by Combination Therapy Regimen

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Treatment of Cancer Improved by Combination Therapy Regimen

 

The Phase 3 trial of Sanofi and Regeneron’s PD-1 inhibitor Libtayo in combination with platinum-doublet chemotherapy was stopped early after meeting its overall survival (OS) primary endpoint in patients with advanced non-small-cell lung cancer (NSCLC). Besides, A new preclinical study suggests that combining immune checkpoint inhibitors targeting PD-1/ PD-L1 with MAPK-targeted therapy—drugs typically used separately— may help overcome cancer treatment resistance.

 

More and more studies have shown that immune checkpoint combination therapy has a good effect in dealing with cancer.

  

ACROBiosystems has developed an exclusive immune checkpoint protein collection. 

 

Product Features

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  • High purity verified by MALS or HPLC.
  • High bioactivity verified by ELISA/SPR/FACS, etc.
  • High batch to batch consistency by strict QC
     tested

 

Main Applications:

      Immunization and antibody screening

      Cell-based assay

      Pharmacokinetic analysis

 

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Wonder how can these immune checkpoint proteins help your drug development?

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Assay Data

The protocols are available for free!

 

  • Authentic structure verified by SEC-MALS

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Figure 1. The purity of Human CD27 Ligand, His, Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H52Da) was more than 95% in HP-SEC, and around 55-70 kDa verified by SEC-MALS. 

 

  • Cell-based assay

Cell-based_assay.jpgFlow Cytometry assay shows that Human PD-1, Fc Tag, low endotoxin (Cat. No. PD1-H5257) can bind to 293 cells overexpressing human PD-L1. The concentration of PD-1 used is 1 μg/mL (Routinely tested).

 

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