The new released article Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab published on Science by Genentech team highlights the importance of having intact CD20 for antibody drug development. The team confirmed that the secondary ECL1/2 epitope and Fab: Fab interface contribute to the unique binding properties and high CDC activity of rituximab.

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Lionel Rougé, et al. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab. Science. 2020

To help CD20 antibody drug development, the HEK293 expressed full length CD20 from ACROBiosystems has been very attractive to customers.

HEK293 Expressed Full Length CD20 Proteins with Nanodisc / DDM

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※ Full length CD20 protein has a complete conformation with both small and big loops.

※ Different types of CD20 proteins with Nanodisc / DDM.

• Nanodisc      - Membrane proteins can be integrated into nanodiscs to maintain their biological activity.

• DDM      - Help to maintain and protect the hydrophobic transmembrane structure of membrane proteins.

※ Suitable for immunization, ELISA, SPR, BLI and FACS.

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Product List

Molecule	Cat. No.	Host	Type	Tag	Protocols
CD20/MS4A1	CD0-H52H3	HEK293	Unconjugated, DMM	His Tag	Request BLI/ SPR/ ELISA Protocols
	CD0-H82E5	HEK293	Biotinylated, DMM	His tag & Avitag™	Request FACS Protocol
	CD0-H82E3	HEK293	Biotinylated, Nanodisc	His tag & Avitag™	Request FACS Protocol

 

Latest Research on CD20 Target
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
First release on 20 February 2020 on Science by Genentech

 

 

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