Alomone Labs社 Antibody Explorer Kit : 抗GPCR抗体セット
Alomone Labs社では、GPCR（G-protein-coupled receptor：Gタンパク質共役型受容体）に対する抗体のセットを販売しています。セット内容は、Adrenoceptor Antibody Explorer Kitを例に挙げると、Adrenoceptor α1A, α1B, α1D, α2A, α2B, α2C, β2, β3それぞれに対する抗体がセットされています。コントロールとしてそれぞれの抗体のペプチド抗原が添付されます。
● Adrenoceptor Antibody Explorer Kit
Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.
The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.
The Adrenoceptors are divided into three types: α1, α2 and β adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3. They are expressed in nearly all peripheral tissues and in the central nervous system1,2.
Alomone Labs is pleased to offer the Adrenoceptor Antibody Explorer Kit (#AK-101). This Explorer Kit includes antibodies targeted against adrenoceptors along with their respective peptide control antigen. An ideal tool for screening purposes.
Anti-α1A-Adrenoceptor (extracellular) #AAR-015 1 x 50 µl
Anti-α1B-Adrenoceptor (extracellular) #AAR-018 1 x 50 µl
Anti-α1D-Adrenoceptor (extracellular) #AAR-019 1 x 50 µl
Anti-β2-Adrenoceptor (extracellular) #AAR-016 1 x 50 µl
● Dopamine Receptor Antibody Explorer Kit
DA receptors belong to the G-protein coupled receptors superfamily, and are prominent in the vertebrate central nervous system (CNS) as well as the peripheral nervous system (PNS). The neurotransmitter dopamine, a precursor of noradrenaline and adrenaline, is one of the main endogenous catecholamine ligand for DA receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5, based on their sequence homology, pharmacology and functional properties. Several neuropsychiatric disorders are derived from abnormal dopamine receptor signaling and dopaminergic nerve dysfunction.
Alomone Labs is pleased to offer the Dopamine Receptor Antibody Explorer Kit (#AK-102). This Explorer Kit includes antibodies directed to all five Dopamine receptors along with their respective peptide control antigen. An ideal tool for screening purposes.
Anti-D1 Dopamine Receptor #ADR-001 1 x 50 µl
Anti-D2 Dopamine Receptor (extracellular) #ADR-002 1 x 50 µl
Anti-D3 Dopamine Receptor (extracellular) #ADR-003 1 x 50 µl
● mGluR Antibody Explorer Kit
Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi.
Alomone Labs is pleased to offer the mGluR Antibody Explorer Kit (#AK-103). This Explorer Kit includes antibodies targeted against Glutamate receptors along with their respective peptide control antigen. An ideal tool for screening purposes.
Anti-mGluR1 (extracellular) #AGC-006 1 x 50 µl
Anti-mGluR2 (extracellular) #AGC-011 1 x 50 µl
Anti-mGluR3 (extracellular) #AGC-012 1 x 50 µl
Anti-mGluR4 (extracellular) #AGC-014 1 x 50 µl
Anti-mGluR5 (extracellular) #AGC-007 1 x 50 µl
Anti-mGluR6 (extracellular) #AGC-026 1 x 50 µl
Anti-mGluR7 (extracellular) #AGC-017 1 x 50 µl
Anti-mGluR8 (extracellular) #AGC-028 1 x 50 µl
● Muscarinic Receptor Antibody Explorer Kit
Alomone Labs is pleased to offer the Muscarinic Receptor Antibody Explorer Kit (#AK-206). The Explorer Kit contains muscarinic receptor antibodies with their respective peptide control antigen. An ideal tool for screening purposes.
Anti-M1 Muscarinic Receptor #AMR-001 1 x 50 µl
Anti-M1 Muscarinic Receptor (443-458) #AMR-010 1 x 50 µl
Anti-M2 Muscarinic Receptor #AMR-002 1 x 50 µl
Anti-M3 Muscarinic Receptor #AMR-006 1 x 50 µl
Anti-M4 Muscarinic Receptor #AMR-004 1 x 50 µl
Anti-M5 Muscarinic Receptor (extracellular) #AMR-005 1 x 50 µl
● nAChR Antibody Explorer Kit
Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (nAChRs) which belong to the ligand-gated ion channel superfamily. nAChRs also respond to nicotine, hence their name.
To date, 17 different but related subunits of nAChRs have been identified and cloned. They consist of α subunits (α1-10), which is responsible for the binding of ligands. In fact, this subunit includes a Cys-loop in the first extracellular domain that is required for agonist binding. The other subunits responsible for making up the active receptor are the β (β1-4), γ, δ and ε subunits. Structurally, all subunits have the following: a conserved large extracellular N-terminal domain, 3 conserved transmembrane domains, a variable cytoplasmic loop and a fourth transmembrane domain with a short extracellular C-terminal domain. An active nAChR is generally a heteropentamer (homopentamers also exist) of these various subunits organized around a central pore.
Alomone Labs is pleased to offer the nAChR Antibody Explorer Kit (#AK-203). This Explorer Kit includes antibodies targeted against nAChRs along with their respective peptide control antigen. An ideal tool for screening purposes.
Anti-Nicotinic Acetylcholine Receptor α1 (extracellular) #ANC-001 1 x 50 µl
Anti-Nicotinic Acetylcholine Receptor α2 (extracellular) #ANC-002 1 x 50 µl
Anti-Nicotinic Acetylcholine Receptor α3 (extracellular) #ANC-003 1 x 50 µl
Anti-Nicotinic Acetylcholine Receptor α6 (extracellular) #ANC-006 1 x 50 µl
Anti-Nicotinic Acetylcholine Receptor β2 (extracellular) #ANC-012 1 x 50 µl
● P2Y Receptor Antibody Explorer Kit
Hypoxia or inflammation, activates the release of extracellular nucleotides such as ATP and UTP which interact with cell surface P2Y receptors to produce a broad range of physiological responses including cardiac function, platelet aggregation and smooth muscle cell proliferation. Eight mammalian P2Y receptors, members of G-protein coupled receptors, have been identified on the basis of sequence homology and pharmacological profile: the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14.
Alomone Labs is pleased to offer the P2Y Receptor Antibody Explorer Kit (#AK-100). This Explorer Kit includes antibodies directed to purinergic P2Y receptors.
Anti-P2Y1 Receptor #APR-009 1 x 50 µl
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