Alomone Labs社 Of Mitochondria and Stiff Hearts

Of Mitochondria and Stiff Hearts

Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in the 5–15 age bracket. HCM primarily occurs because mutations in cardiac sarcomeres render the heart stiff and overactive. New work using a novel in vitro model of cardiac stiffening establishes an intriguing link between L-type calcium channels and mitochondria.

New Products

Membrane Protein Immunodetection

Primary Antibodies:

Guinea pig Anti-D₁ Dopamine Receptor Antibody

Cat #: ADR-001-GP
Type: Polyclonal | Host: Guinea pig | Applications: IF, IHC, WB, *ICC, *IFC, *IP |

Reactivity: H, M, R

Anti-RIM1 Antibody

Cat #: AIP-014
Type: Polyclonal | Host: Rabbit | Applications: WB, *ICC, *IFC, *IHC, *IP |

Reactivity: M, R, *H

Anti-ZnT1 (SLC30A1) Antibody

Cat #: AZT-011
Type: Polyclonal | Host: Rabbit | Applications: IF, IHC, WB, *ICC, *IFC, *IP |

Reactivity: M, R, *H

Anti-EMR1 (ADGRE1) (extracellular) Antibody

Cat #: #AER-051
Type: Polyclonal | Host: Rabbit | Applications: ICC, IF, IFC, LCI, WB, *IHC, *IP |

Reactivity: H, M, R

Antibodies for Live Cell Direct Flow Cytometry:

Anti-Calcium Sensing Receptor (extracellular)-FITC Antibody

Cat #: ACR-004-F
Type: Polyclonal | Host: Rabbit | Applications: FC, LCI, *ICC | Reactivity: H, M, R

Anti-D₂ Dopamine Receptor (extracellular)-FITC Antibody

Cat #: ADR-002-F
Type: Polyclonal | Host: Rabbit | Applications: FC, LCI, *ICC | Reactivity: H, M, R

Ion Channel Pharmacology

Small Organic Molecules:

Pyrrolopyrimidine 48

Cat #: P-275
Type: Small Molecules | Source: Synthetic | MW: 385.46 |

Target: Na_V1.7, Na_V1.5 channels

NS-11021

Cat #: N-335
Type: Small Molecules | Source: Synthetic | MW: 511.24 |

Target: K_Ca1.1, KCNQ4 channels

TCN 201

Cat #: T-190
Type: Small Molecules | Source: Synthetic | MW: 461.89 |

Target: NMDA receptors

TCN 213

Cat #: T-215
Type: Small Molecules | Source: Synthetic | MW: 376.54 |

Target: NMDA receptors

Why Alomone Labs?

Because we've been producing and validating membrane protein molecular tools in-house for decades.

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