Anatrace社 GDN opens new doors for LCP method
GDN has a history of opening doors.
For years, we’ve touted the benefits of using GDN as a synthetic drop-in substitute for Digitonin in Cryo-EM structure determination of membrane proteins. This is based on GDN’s higher solubility, zero batch-to-batch variability, and lower price. Just in the past few months, several exciting new structures have been deposited using GDN. And while there’s no doubt GDN has become an invaluable tool for Cryo-EM structure determination, we’re even more enthused by what we’ve seen most recently.
A recent publication from the lab of Martin Caffrey, has shown that GDN is also compatible with the lipidic cubic phase (LCP) method. In this study, it was reported the cubic phase formed by the host lipid monoolein was not disrupted by GDN over a wide range of concentrations and temperatures. The main takeaway? Membrane proteins solubilized and purified using GDN can proceed directly into LCP crystallization trials. This is exciting news, as the results open more doors to the effective use of GDN in experiments beyond Cryo-EM.
For those of you searching for the right tools for both Cryo-EM and LCP crystallization, we’ve got you covered. Not only do we continue to develop tools and reagents to support the Cryo-EM workflow, including grids, amphipols, lipids, and fluorinated surfactants, we also offer a complete selection of tools and reagents to support the LCP crystallization workflow, like host lipids, plates, and crystallization screens.To read about the recent uses of GDN, and learn about all the tools we offer for both LCP and Cryo-EM applications, visit us here.
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