Liposome is a common transfection approach used to carry DNA or RNA across the cell membrane by lipofection. Liposome entraps the transfected payload, e.g. DNA or RNA in an aqueous environment.

Liposome used for in vivo transfection is termed lipid nanoparticle (LNP). LNP includes four types of molecules: an ionizable amino lipid to bind nucleic acids, an amphipathic phospholipid to promote fusion with the plasma membranes, cholesterol to facilitate LNP stability and polyethylene glycol (PEG) lipid to improve colloidal stability and reduce reticuloendothelial clearance.

BiCellFectamaxVivo Transfection Reagent utilizes a mixture of ionizable cationic lipids 4A3-SC8 and DLin-MC3-DMA, phospholipids DOPE and DSPC, cholesterol, DMG conjugated PEG molecule to form stable LNPs and deliver siRNA, mRNA, and DNA to a variety of internal organs.

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