Suzuki Cross-Coupling

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Palladium-catalyzed cross-coupling is hailed as one of the most advanced tools available to chemists. Among them, the Suzuki cross-coupling starting with organoboron has a wide range of applications in pharmaceutical chemistry and synthesis of natural products as well as organic materials.

Organoboron nucleophiles consist of boronic acid, potassium trifluoroborate, and boronate. Boronic acids are the most reactive and most atom-economic while boronates such as Bpin and Bneop are stable, cheap, and easy preparation. Burke boronates are applied in iterative and automated Suzuki-Miyaura coupling. Potassium trifluoroborate cross-couples efficiently only in the presence of water. All the listed above are suitable for various reaction conditions, showing the difference in reaction activity.

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