With Cytoskeleton Inc. Actin Kits You Can:

• Measure the effects of proteins and drugs on actin polymerization/depolymerization.
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Host–Pathogen Interactions And The Actin Cytoskeleton

Cytoskeleton's August Newsletter is all about host pathogen interactions and the actin cytoskeleton. Learn about how pathogenic bacteria exploit the actin cytoskeleton and its associated molecular machinery.

ROCK1 Mechano-Signaling Dependency Of Human Malignancies Driven By TEAD/YAP Activation

Targeting specific signaling pathways to treat cancer has led to an array of new therapeutics with promising outcomes.   Recently, Esposito et al. sought to investigate the mechanism by which a group of P53 mutants activated the TEAD/YAP transcriptional machinery, and discovered that they do so indirectly through ROCK1-dependent mechanisms as a means to drive oncogenesis. These p53 missense mutations impair p53’s ability to bind its target promoter regions and in their screen were found to enhance TEAD transcription that was mediated via the mevalonate (MVA) pathway.

Above: Schematic of Signaling pathways dysregulated during oncogenesis that regulate TEAD/YAP transcription, and potential targets for therapeutic intervention.

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