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Cytoskeleton社 Activators and Inhibitors For Smal G-Protein Investigation




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Popular G-Switch Activators and Inhibitors 


The G-switch™ line of small G-protein tools has been developed with an emphasis on creating highly potent reagents that target endogenous Rho family proteins and pathways. 




Recent Citations with G-Switch Activators


Shoda T. et al. Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis. Nat Commun. 2021


Xu W. et al. Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity. Mol Biol Cell. 2022







Recent Citations with G-Switch Inhibitors 


McCray B. et al. Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension. Nat Commun. 2021


Landino J. et al. Rho and F-actin self-organize within an artificial cell cortex. Curr Biol. 2021


Talwar S. et al. Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho. Cell Reports. 2021




The G-switch™ product line includes reagents that directly and indirectly modulate Rho family signal transduction, thereby offering a wide range of mechanistic tools to study these critical cellular functions. Click the buttons above to learn more about G-Switch Activators and Inhibitors



Recent G-Switch and Small G Protein Related Writings


Cytoskeleton's April Newsletter


Oncogenic RAS drives cells to the cancerous state through a wide range of mechanisms, including: the establishment of cancer cell plasticity (1), enhancement of cell migration and metastasis (2) and metabolic reprogramming towards anabolic metabolism (3). This Newsletter focuses on the emerging area of RAS driven oncogenesis via the evasion of host immune attack.






Cytoskeleton's March Citation Spotlight


This study investigated the VSMC phenotypic state in response to ECM stiffness and discovered an alternative VSMC null state where traditional VSMC phenotypes emerge from in response to differential Rac and Rho signals







G-LISA Small GTPase Activation Assays

G-LISA Small GTPase Activation Assays offer a fast and sensitive method for performing small G-protein activation assays. Kits are availabe for RhoA, Rac1, Cdc42, and more...


The G-LISA Activation Assays Advantage:


  • High Sensitivity and Accuracy
  • Results in 3 Hours
  • Flexible Format
  • Small Amount of Material Required
  • Compatible with mouse, rat and human tissues and cells



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Small G-protein Tools

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