Recent Citations with G-Switch Activators

Shoda T. et al. Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis. Nat Commun. 2021

Xu W. et al. Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity. Mol Biol Cell. 2022

Recent Citations with G-Switch Inhibitors 

McCray B. et al. Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension. Nat Commun. 2021

Landino J. et al. Rho and F-actin self-organize within an artificial cell cortex. Curr Biol. 2021

Talwar S. et al. Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho. Cell Reports. 2021

Oncogenic RAS drives cells to the cancerous state through a wide range of mechanisms, including: the establishment of cancer cell plasticity (1), enhancement of cell migration and metastasis (2) and metabolic reprogramming towards anabolic metabolism (3). This Newsletter focuses on the emerging area of RAS driven oncogenesis via the evasion of host immune attack.

Cytoskeleton's March Citation Spotlight

This study investigated the VSMC phenotypic state in response to ECM stiffness and discovered an alternative VSMC null state where traditional VSMC phenotypes emerge from in response to differential Rac and Rho signals

The G-LISA Activation Assays Advantage:

• High Sensitivity and Accuracy
• Results in 3 Hours
• Flexible Format
• Small Amount of Material Required
• Compatible with mouse, rat and human tissues and cells

Small G-protein Tools