Cytoskeleton社 December 2022 Newsletter: Microproteins
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Small but Mighty: The Emerging World of Microproteins |
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During initial efforts to annotate genomes, many potential coding sequences were identified that were assumed to be too short to encode functional proteins. To reduce the number of annotations and reduce the risk of false positives, an arbitrary cutoff was therefore applied, and sequences shorter than 100 amino acids (aa) were filtered out.1 Later, it was discovered that many of these small open reading frames (smORFs) are translated to produce microproteins, or micropeptides, whose expression is apparently just as tightly controlled as for canonical proteins.1,2 |
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Past Topics - Click Each Title for More Info
· Cell Membrane Manipulation by Scramblases · Disturbances in the Filamentous Actin Cytoskeleton Appear in Alzheimer’s Disease · RhoA/ROCK Signaling in Cardiac Pathophysiology · Host-Pathogen Interactions and the Actin Cytoskeleton · Repurposing Colchicine to Treat Covid-19 · Controlling Ubiquitination is Key in The War With Bacteria · Oncogenic RAS Signaling And Tumor Immune Evasion: Mechanisms And Therapeutic Opportunity · Recent Discoveries on ABP’s and their Effect on Synaptic Plasticity · The Cytoskeleton's Role in Autism Spectrum Disorder
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