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Cytoskeleton社 Differences in CD80 and CD86 transendocytosis a role for Ubiquitination


CD80_and_CD86_1.jpgDifferences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Dysfunctional T cell response can lead to abnormal immune function and the progression of immune-related pathologies. CTLA-4 receptors function as a negative regulator of T cell response by effectively suppressing activation, and it has been shown that mutations in CTLA-4 led to deleterious auto-immune effects. Two ligands, CD80 and CD86, both bind CTLA-4, but it is not fully understood how these ligands differ in their effect on CTLA-4. Sansom and colleagues recently showed that binding properties of these ligands to CTLA-4 resulted in distinct differences in CTLA-4 fate during transendocytosis which affected their ability to regulate autoimmunity...


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CD80_and_CD86_2.gifAbove: Schematic showing high avidity binding of CD80 and CTLA-4, which results in ubiquitination of CTLA-4, transendocytosis, and lysosomal degradation. 


Link to Citation:


Kennedy A. et al. Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation. Nat Immunol. 2022 Sep;23(9):1365-1378. doi: 10.1038/s41590-022-01289-w.


Related Products/Products Used:


Ubiquitination Affinity Beads - 40 Assays (CAT. # UBA01-Beads)



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