Cytoskeleton社 ECM Tools: Labeled Fibronectin and Laminin
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Purified Extra Cellular Matrix Tools from Cytoskeleton Inc.
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The Extracellular Matrix (ECM) is composed of collagen, non-collagenous glycoproteins, and proteoglycans. These components are secreted from cells to create an ECM meshwork that surrounds cells and tissues. The ECM regulates many aspects of cellular function, including the cells' dynamic behavior, cytoskeletal organization, and intercellular communication.
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Applications of Cytoskeleton ECM Tools
FNR01 - Measuring the effects of metalloproteinase on ECM using Rhodamine Fibronectin
FNR01, FNR02, LMN01, LMN02 - In vitro invadopodia / podosome invasion assays
FNR02 -Fibronectin assembly studies
FNR01 -Measuring membrane dynamics in tissue culture using rhodamine fibronectin
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Check out these recent ECM citations
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MYO10-Filopodia Support Basement Membranes At Pre-Invasive Tumor Boundaries
The transition from benign ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC) involves the escape of cells through a breach of the basement membrane (BM) that surrounds the DCIS. There has been significant progress in understanding how cancer cells penetrate through BMs, but less is known about how cancer cell progression itself impacts the BM. A recent study by the Ivaska lab identified that Myosin-X (MYO10), an inducer of filipodia....
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Above: Effects of MYO10-filipodia on breast cancer during tumor progression. |
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Stimulation Of Fibronectin Matrix Assembly By Lysine Acetylation
One of the major complications of diabetes is diabetic nephropathy, with fibrosis being a hallmark of the disease. Excess deposition of ECM, produced by mesangial cells, occurs in the glomeruli. Fibronectin (FN), a major component of the mesangial ECM, is an abundant and ubiquitous ECM protein important for interactions between cells and the surrounding matrix. Vega et al. investigated the effects of acetylation on FN assembly and identified acetylated β1 integrin as a mediator of cell-FN interactions and downstream FN... Click to read more
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Aboce: Schematic representation of acetylated integrin interacting with ECM |
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Learn More About Each ECM Protein Below 
Above: MCF10A cells treated with fluorescent rhodamine fibronectin (Cat. # FNR01). Image kindly provided by A. Varadaraj and M. Karthikeyan, University of South Carolina, Columbia, SC.
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