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Cytoskeleton社 Molecular mapping of neuronal architecture using STORM microscopy and MemGlow Fluorescent probes



Molecular Mapping of Neuronal Architecture Using STORM Microscopy and New Fluorescent Probes for SMLM Imaging


Tools and methodologies that enable precise imaging of neuronal architecture are in great demand as scientists seek to effectively analyze the structure of synapses and their associated proteins. Recently the Danglot group reported on new software in combination with membrane labeling probes to detect pre and postsynaptic proteins. The statistical object distance analysis (SODA) software effectively analyzes cellular shape and spot density and was able to detect distances between two synapse-associated proteins synapsin and PSD95. Importantly, the SODA software was even used to perform 3D analysis, making it suitable for use with thick 3D volume STORM images...


Figure Legend: Schematic of the SODA protocol used for spatial distance analysis. This figure was adapted from Breton et al. 2024. Neurophotonics. doi: 10.1117/1.NPh.11.1.014414.

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The Kinesin-5 Tail And Bipolar Minifilament Domains Are The Origin Of Its Microtubule Crosslinking And Sliding Activity

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SUMO Monoclonal Antibodies Vary In Sensitivity, Specificity, And Ability To Detect Types Of SUMO Conjugate

The kinesin-5 motor protein plays an essential role in mitotic spindle assembly through its interaction and sliding of microtubules. Kinesin-5 has several key domains including its c-terminal tail domains, N-terminal motor domains, and its bipolar assembly domain which is critical for its tetrameric bundling...


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The post-translational modification, small ubiquitin-like modifier (SUMO) can be conjugated to target proteins to control its localization, activity, and protein interactions. These SUMOylation events are critical for many cellular processes and have been shown to be misregulated in a multitude of diseases...


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