Cytoskeleton社 MYO10-filopodia support basement membranes in DCIS
この製品に関するご意見・ご照会・お問合せはこちら
MYO10-filopodia support basement membranes at pre-invasive tumor boundaries
|
The transition from benign ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC) involves the escape of cells through a breach of the basement membrane (BM) that surrounds the DCIS. There has been significant progress in understanding how cancer cells penetrate through BMs, but less is known about how cancer cell progression itself impacts the BM. A recent study by the Ivaska lab identified that Myosin-X (MYO10), an inducer of filipodia, has a profound effect on BM formation around DCIS, and may play opposing roles in early vs late breast cancer progression. Preliminary studies from human patient samples showed elevated levels of MYO10 in DCIS and IBS relative to normal mammary epithelium.
Read More |
Above: Effects of MYO10-filipodia on breast cancer during tumor progression. |
Link to Citation:
Peuhu E. et al. MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. Dev Cell. 2022 Oct 24;57(20):2350-2364.e7. doi:10.1016/j.devcel.2022.09.016.
Related Products/Products Used
Fibronectin (Green Fluorescent, HiLyte 488) (Cat. # FNR02)
Laminin (Green Fluorescent, HiLyte 488) (Cat. # LMN02)
Visit Our Blog for
Newsletter, Citations, Upcoming Sales, and New Products
|
Recent Citation Spotlights
November 2022
Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants |
October 2022
Global Ubiquitinome Profiling Identifies NEDD4 As A Regulator Of Profilin 1 And Actin Remodeling In Neural Crest Cells |
A mechanism important during asymmetric cell division in development is the polarized trafficking of endosomes, as this leads to differential levels of critical signaling proteins that control cell fate. Recently, Planelles-Herrero et al. identified a critical protein complex known as Elongator which is essential to control spindle asymmetry through the regulation of microtubules...
Read More |
Neural crest cell (NCC) development occurs through the regulation of key transcription factors and its downstream effector genes. However, recent studies suggest additional regulatory mechanisms such as post-translational modifications also have important roles; specifically, Schwarz and colleagues identified the ubiquitin ligase...
Read More |
|
Fount of Information は、新商品、新規取扱メーカーなどの情報をいち早く紹介するコンテンツです。情報発信のスピードを重視しているコンテンツのため、現時点で法規制や取り扱いを確認できていない商品、定価を設定できていない商品があります。ご要望やご照会を受けた商品について、法令整備や在庫の充実を図ります。