Cytoskeleton社 Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions
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Transient receptor potential vanilloid 4 (TRPV4) is a homotetrameric ion channel that coordinates a variety of cellular processes in response to extracellular environmental stimuli. Interestingly, mutations in TRPV4 result in an array of pathologies such as neuropathy and skeletal dysplasia; nonetheless, the cause of these diseases appears to have a common underlying factor, that is, a dysfunction in cytoskeletal processes. Recently, McCray et al. sought to understand the mechanisms by which TRPV4-mutations alter cytoskeletal function and neuropathy. ...
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 Above: Schematic for TRPV4–RhoA functional interactions. Inactive TRPV4 channels bind GDP-bound RhoA. Activation of TRPV4 ion channel leads to release of RhoA, calcium-dependent RhoA activation, and enhanced cytoskeletal changes. |
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Related Products/Products Used
Exoenzyme C3 Transferase Protein: His Tagged:Clostridium Botulinum Recombinant (Cat. # CT03)
Cdc42 Pull-Down Activation Assay Biochem Kit (Bead Pull-Down Format) - (Cat. # BK034)
Rac1 Pull-Down Activation Assay Biochem Kit (Bead Pull-Down Format) - (Cat. # BK035)
RhoA Pull-Down Activation Assay Biochem Kit (Bead Pull-Down Format) - (Cat. # BK036)
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