The small G-protein RhoA, functions as a molecular switch through interactions with GTP and GDP, to regulate an array of cellular processes including cell proliferation, cell shape, and cytoskeletal regulation. Seminal studies by Ridley and Hall showed that RhoA was activated by serum stimulation[1]; additionally, it is now appreciated that RhoA is a critical signaling mediator for some G protein-coupled receptors (GPCRs) (reviewed in [2]). GPCR signaling plays a fundamental role in cardiac physiology, and dysregulation of these signaling mechanisms has deleterious effects on many cardiovascular diseases including heart failure (reviewed in [3]). These pathways are so critical in cardiac disease, that drugs that target GPCRs are considered the standard of therapy for many cardiovascular diseases...

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