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Cytoskeleton社 Stem cell dynamics regulation by Plexin-B2 via actomyosin contractility




Plexin-B2 Orchestrates Collective Stem Cell Dynamics Via Actomyosin Contractility, Cytoskeletal Tension and Adhesion


Multicellular organization requires rapid changes in biomechanical dynamics and establishment of a collective actomyosin network in order to maintain cell morphology. How human embryonic stem cells (hESCs) orchestrate cytoskeletal tension across cells and organize adhesion complexes to maintain cytoarchitectural integrity is incompletely understood. Recent work by the Friedel lab identified a key role for Plexin-B2 in the control of actomyosin contractility and adhesion properties in hESCs. Plexin-B2 is an axon guidance receptor that has been shown to mediate cellular interactions in a variety of tissue contexts. The group utilized Plexin-B2 CRISPR KO hESCS (B2-KO) as well as lentiviral Plexin-B2 overexpressing hESCs [B2-OE] to show that dysregulation of Plexin-B2 severely alters hESC colony expansion and ...

Signal_pathway.gifAbove Schematic: Plexin-B2 signaling with mechanoregulation in stem cells


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Link to Citation:


Chrystian Junqueira Alves et al. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion. Nat Commun. 2021 Oct 14;12(1):6019. doi: 10.1038/s41467-021-26296-7.


Related Products/Products Used


Spy-555 Actin (Cat. # CY-SC202)

MemGlow™ 488: Fluorogenic Membrane Probe (A Member Of The MEMBRIGHT™ Family) (Cat. # MG01)


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