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Cytoskeleton社 Succinylation of APP and Tau in Alzheimer's Disease





Altered Succinylation of Mitochondrial Proteins, APP and Tau in Alzheimer’s Disease


Reduced glucose metabolism in specific brain regions has been shown to correlate with clinical cognitive dysfunction, and preclinical research studies showed that reduced glucose metabolism can amplify learning and memory deficits. A recent study by Yang et al.  showed that succinylation, a metabolism-associated PTM, provides a potential link between abnormal metabolism and Alzheimer's disease (AD) pathology. Surprisingly, in AD patients, succinylation of a small number of cytosolic proteins increased, and two targets in particular were amyloid precursor protein (APP) and microtubule-associated tau...


Above: Schematic of Succinylation and Desuccinylation of target proteins


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Link to Citation:


Yang Y. et al. Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease. Nat Commun. 2022 Jan 10;13(1):159. doi: 10.1038/s41467-021-27572-2.


Related Products/Products Used


Tubulin protein (>99% pure): porcine brain (Cat. # T240)


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