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Cytoskeleton社 Galectin-8- and Fibronectin-Coated Substrates Analysis





Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates


The extracellular matrix (ECM) is a structural network consisting of extracellular macromolecules, such as collagen, fibronectin, glycoproteins and laminin that provide support to surrounding cells through facilitating cell adhesion, cell differentiation, and cell-to-cell communication. Many studies have investigated the regulatory mechanisms activated by ECM proteins but, but there is still much to learn. A recent study by Li. et al. systematically investigated fibronectin and galectin-8 effects on cellular responses either alone or in combination. Detailed time course studies of Hela cells grown on fibronectin or galectin-8 coated substrates revealed distinctly different...


 Above: Schematic Cell spreading on substrates comprised of Fibronectin vs Galectin-8.

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Link to Citation:


Li W. et al. Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates. J Cell Sci. 2021 Apr 15;134(8):jcs252221. doi: 10.1242/jcs.252221. Epub 2021 Apr 27.


Related Products/Products Used


Fibronectin (Green Fluorescent, HiLyte 488) (Cat. # FNR02)


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