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LifeSensors社 LifeSensors and the New Developments in the Ubiquitin Proteasome System


LifeSensors and the New Developments in the Ubiquitin Proteasome System

The ubiquitylation reaction is a sequential process mediated by three enzymes.pngThe ubiquitylation reaction is a sequential process mediated by three enzymes: E1, E2, and E3.


LifeSensors’ TUBEs

●LifeSensors has developed TUBEs (Tandem Ubiquitin Binding Entities) for detecting and isolating poly-ubiquitin proteins.

●We have developed Pan Selective TUBEs and poly-ubiquitin chain selective TUBEs lysine 48, lysine 63, and Linear/M1.


  ○Enrichment of poly-ubiquitylated proteins 

  ○Monitoring the formation of new poly-ubiquitin chains as part of an E3 ligase assay 

  ○Detection of poly-ubiquitylated proteins by western blots in a more efficient manner than antibodies

  ○Imaging of cells, organelles, or tissue

TUBEs and PROTAC Discovery

PROTAC (Protein Targeting Chimera) molecules can be used to hijack the Ubiquitin Proteasome System to degrade disease associated proteins.

●TUBEs allow for the detection of the poly-ubiquitylated protein prior to its degradation, thus establishing the PROTAC drug function.

●LifeSensors has developed plate-based High-Throughput Screening (HTS) methods to detect PROTAC ubiquitylation.

●Advantages of LifeSensors' technologies over others available on the market:

  ○Provide more information on the state of the protein

  ○Only PROTAC targeted assay that can establish poly-ubiquitination and subsequent degradation in rapid HTS fashion 

  ○Do not require establishing stable cell lines

  ○Allow for testing in more physiologically relevant conditions

  ○Poly-ubiquitin chain selective platforms to decode complex PROTAC mechanisms

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