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TUBE Technology Identifies Role of Ligase in Inflammation Pathway


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• Studying the necrosome, a central signaling complex involved in inflammation, is critical to understanding immune cell function.

• Researchers determined that Triad3a acts as the primary E3 ligase for Ripk1 proteasomal degradation.

• Developing UPS modulators to shut off necrosome signalling is a promising target for inflammatory disease.

These important discoveries were made possible with LifeSensors'

GST-tagged TUBE (UM102).

TUBE Technology

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