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OriGene社 Alzheimer's Disease: Biomarkers and Latest discoveries

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OriGene_Header.pngAlzheimer's disease (AD) is the most common neurodegenerative disorder characterized by dementia that generally initiates with a subtle failure of memory, progressing over the years to an incapacitating level. It is characterized by extracellular amyloid plaques and intracellular neurofibrillary tangles, resulting in neuronal dysfunction and cell death.

The two most popular targets in AD research are 



The generation of the Beta-Amyloid (Aβ) peptide through the proteolytic processing of the Amyloid precursor protein (APP) is a central event in the pathogenesis of AD. Extracellular accumulation of Aβ leads to forming aggregates, fibrils, and eventually, amyloid deposits called neuritic plaques, a hallmark of AD.

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Tau is a microtubule-associated protein (MAP) involved in microtubule stabilization. In Alzheimer's, tau becomes hyperphosphorylated and detaches from microtubules. Phosphorylated tau then aggregates to form paired helical filaments (PHFs) and neurofibrillary tangles (NFTs)

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Latest Discoveries in AD research

Scientists developed an antibody-based blood test that would detect brain-derived tau to predict deposits in the brain

Other related markers


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