The Cas9 endonuclease is perhaps one of the most well known proteins due to its role in the natural CRISPR system that aids in bacterial adaptive immunity. Although there have been promising advancements in CRISPR technology, a recent study published by Höijer et al, noted that CRISPR can result in off target cuts and/or mutations that can be passed through generations. The power of the  CRISPR-Cas9 is undeniable but until more research reveals how to avoid these mistakes, the system must be used with caution and requires extensive validation. Click here to read the full article.

OriGene offers a complete set of Cas9 products from purified proteins and specific antibodies. All of them are created based on wild type Streptococcus pyogenes Cas9 protein.

TP790148 CAS9 recombinant protein	TA160001 CAS9 Mouse Monoclonal Antibody	TA190309 Rabbit polyclonal CAS9 antibody

Why Use OriGene's Cas9 Protein? Sterile protein with NLS signals High RNA-guided endonuclease activity High genome editing efficiency  High protein concentration & purity